Kheir M M, Wang Y,Hua L,et al. Acute toxicity of berberine and its correlation with the blood concentration in mice[J]. Food Chem Toxicol, 2010,48(4):1105.
[3]
Ma B L, Ma Y M, Shi R,et al. Identification of the toxic constituents in Rhizoma Coptidis[J]. J Ethnopharmacol, 2010,128(2):357.
[4]
Moody J O, Ogundipe O D, Akang E U,et al. Toxicological studies on the purified protoberberine alkaloidal fraction of Enantia chlorantha Oliv (ANNONACEAE)[J]. Afr J Med Med Sci, 2007,36(4):317.
[5]
Joshi P V, Shirkhedkar A A, Prakash K,et al. Antidiarrheal activity, chemical and toxicity profile of berberis aristata[J]. Pharm Biol, 2011,49(1):99.
[6]
Ma B L, Ma Y M, Gao C L,et al. Lipopolysaccharide increased the acute toxicity of the Rhizoma coptidis extract in mice by increasing the systemic exposure to Rhizoma Coptidis alkaloids[J]. J Ethnopharmacol, 2011,138(1):169.
[7]
Dunnick J K, Singh B, Nyska A,et al. Investigating the potential for toxicity from long-term use of the herbal products, goldenseal and milk thistle[J]. Toxicol Pathol, 2011,39(2):398.
[8]
Jahnke G D, Price C J, Marr M C,et al. Developmental toxicity evaluation of berberine in rats and mice[J]. Birth Defects Res B Dev Reprod Toxicol, 2006,77(3):195.
[9]
Pasqual M S, Lauer C P, Moyna P,et al. Genotoxicity of the isoquinoline alkaloid berberine in prokaryotic and eukaryotic organisms[J]. Mutat Res,1993,286(2):243.
[10]
Marazzi G, Cacciotti L, Pelliccia F,et al. Long-term effects of nutraceuticals (berberine, red yeast rice, policosanol) in elderly hypercholesterolemic patients[J]. Adv Ther, 2011,28(12):1105.
[11]
Cianci A, Cicero A F, Colacurci N,et al. Activity of isoflavones and berberine on vasomotor symptoms and lipid profile in menopausal women[J]. Gynecol Endocrinol, 2012,28(9):699.
[12]
Di Pierro F, Villanova N, Agostini F,et al. Pilot study on the additive effects of berberine and oral type 2 diabetes agents for patients with suboptimal glycemic control[J]. Diabetes Metab Syndr Obes, 2012,5:213.
Linn Y C,Lu J, Lim L C,et al. Berberine-induced haemolysis revisited: safety of Rhizoma Coptidis and Cortex Phellodendri in chronic haematological diseases[J].Phytother Res,2012,26(5):682.
Yifei Zhang,Xiaoying Li,Dajin Zou,et al.Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine[J].J Clin Endocrinol Metab, 2008, 93(7):2559.
[42]
Hu Y, Ehli E A, Kittelsrud J,et al. Lipid-lowering effect of berberine in human subjects and rats[J]. Phytomedicine,2012,19(10):861.
[43]
Zeng X H, Zeng X J, Li Y Y. Efficacy and safety of berberine for congestive heart failure secondary to ischemic or idiopathic dilated cardiomyopathy[J]. Am J Cardiol, 2003,92(2):173.
[44]
Yin J, Xing H, Ye J. Efficacy of berberine in patients with type 2 diabetes mellitus[J]. Metabolism, 2008,57(5):712.
