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中国陕西地方性骨关节病软骨中线粒体功能紊乱相关通路

, PP. 861-867

Keywords: 大骨节病,微阵列芯片,线粒体功能紊乱,IPA通路分析

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Abstract:

采用线粒体相关基因表达和IPA方法,对705个线粒体相关基因的基因表达进行分析.基于线粒体相关基因平均表达比值比,分析获得大骨节病软骨9个显著性上调差异表达的线粒体相关基因;通路分析发现大骨节病软骨氧化磷酸化、丙酮酸盐代谢和凋亡信号通路上调,提示软骨细胞线粒体功能紊乱在大骨节病发病机制中起重要作用.

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