4 Soulier J, Grollet L, Oksenhendler E, et al. Kaposi’s sarcoma-associated herpesvirus-like DNA sequences in multicentric Castleman’s disease. Blood, 1995, 86: 1276-1280
[2]
5 Lee B S, Connole M, Tang Z, et al. Structural analysis of the Kaposi’s sarcoma-associated herpesvirus K1 protein. J Virol, 2003, 77: 8072-8086？？
[3]
6 Moore P S, Chang Y. Molecular virology of Kaposi’s sarcoma-associated herpesvirus. Philos Trans R Soc Lond B Biol Sci, 2001, 356: 499-516？？
[4]
7 Staskus K A, Zhong W, Gebhard K, et al. Kaposi’s sarcoma-associated herpesvirus gene expression in endothelial (spindle) tumor cells. J Virol, 1997, 71: 715-719
[5]
8 Bais C, Santomasso B, Coso O, et al. G-protein-coupled receptor of Kaposi’s sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator. Nature, 1998, 391: 86-89？？
[6]
9 Martin D, Galisteo R, Molinolo A A, et al. PI3Kγ mediates Kaposi’s sarcoma-associated herpesvirus vGPCR-induced sarcomagenesis. Cancer Cell, 2011, 19: 805-813？？
[7]
10 Jham B C, Montaner S. The Kaposi’s sarcoma-associated herpesvirus G protein-coupled receptor: lessons on dysregulated angiogenesis from a viral oncogene. J Cell Biochem, 2010, 110: 1-9
[8]
11 Martin D, Galisteo R, Ji Y, et al. An NF-kB gene expression signature contributes to Kaposi’s sarcoma virus vGPCR-induced direct and paracrine neoplasia. Oncogene, 2008, 27: 1844-1852？？
[9]
18 Holst P J, Rosenkilde M M, Manfra D, et al. Tumorigenesis induced by the HHV8-encoded chemokine receptor requires ligand modulation of high constitutive activity. J Clin Invest, 2001, 108: 1789-1796
[10]
19 Ho H H, Du D, Gershengorn M C. The N terminus of Kaposi’s sarcoma-associated herpesvirus G protein-coupled receptor is necessary for high affinity chemokine binding but not for constitutive activity. J Biol Chem, 1999, 274: 31327-31332？？
[11]
20 Geras-Raaka E, Varma A, Ho H, et al. Human interferon-gamma-inducible protein 10 (IP-10) inhibits constitutive signaling of Kaposi’s sarcoma-associated herpesvirus G protein-coupled receptor. J Exp Med, 1998, 188: 405-408？？
[12]
21 Feng H, Sun Z, Farzan M R, et al. Sulfotyrosines of the Kaposi’s sarcoma-associated herpesvirus G protein-coupled receptor promote tumorigenesis through autocrine activation. J Virol, 2010, 84: 3351-3361？？
[13]
22 Feng H, Dong X, Negaard A, et al. Kaposi’s sarcoma-associated herpesvirus K7 induces viral G protein coupled receptor degradation and reduces its tumorigenicity. PLoS Pathog, 2008, 4: e1000157？？
[14]
1 Chang Y, Cesarman E, M S Pessin, et al. Identification of herpesvirus-like DNA sequences in AIDS-associated Kaposi’s sarcoma. Science, 1994, 266: 1865-1869？？
[15]
2 Cesarman E, Chang Y, Moore P S, et al. Kaposi’s sarcoma-associated herpesvirus-like DNA sequences in AIDS-related body-cavity-based lymphomas. N Engl J Med, 1995, 332: 1186-1191？？
[16]
3 Nador R G, Cesarman E, Knowles D M, et al. Herpes-like DNA sequences in a body-cavity-based lymphoma in an HIV-negative patient. N Engl J Med, 1995, 333: 943
[17]
12 Pati S, Foulke Jr J S, Barabitskaya O, et al. Human herpesvirus 8-encoded vGPCR activates nuclear factor of activated T cells and collaborates with human immunodeficiency virus type 1 Tat. J Virol, 2003, 77: 5759-5773？？
[18]
13 Emuss V, Lagos D, Pizzey A, et al. KSHV manipulates Notch signaling by DLL4 and JAG1 to alter cell cycle genes in lymphatic endothelia. PLoS Pathog, 2009, 5: e1000616？？
[19]
14 Montaner S, Sodhi A, Molinolo A, et al. Endothelial infection with KSHV genes in vivo reveals that vGPCR initiates Kaposi’s sarcomagenesis and can promote the tumorigenic potential of viral latent genes. Cancer Cell, 2003, 3: 23-36？？
[20]
15 Cannon M, Philpott N J, Cesarman E. The Kaposi’s sarcomaassociated herpesvirus G protein-coupled receptor has broad signaling effects in primary effusion lymphoma cells. J Virol, 2003, 77: 57-67？？
[21]
16 Yang T Y, Chen S C, Leach M W, et al. Transgenic expression of the chemokine receptor encoded by human herpesvirus 8 induces an angioproliferative disease resembling Kaposi’s sarcoma. J Exp Med, 2000, 191: 445-454？？
[22]
17 Gershengorn M C, Geras-Raaka E, Varma A, et al. Chemokines activate Kaposi’s sarcoma-associated herpesvirus G protein-coupled receptor in mammalian cells in culture. J Clin Invest, 1998, 102: 1469-1472？？
