1 Ninane G, Joly J, Kraytman M, et al. Bronchopulmonary infection due to β-lactamase-producing Branhamella catarrhalis treated with amoxycillin/clavulanic-acid. Lancet, 1978, 2: 257
[2]
2 Xiang S H, Li J, Yin H, et al. Application of a double-reporter-guided mutant selection method to improve clavulanic acid production in Streptomyces clavuligerus. Metab Eng, 2009, 11: 310–318？？
[3]
3 Foulstone M, Reading C. Assay of amoxicillin and clavulanic acid, the components of Augmentin, in biological fluids with high-performance liquid chromatography. Antimicrob Agents Chemother, 1982, 22: 753–762
[4]
4 Gutman A L, Ribon V, Leblanc J P. Rapid and convenient spectrophotometric method for determination of clavulanic acid. Anal Chem,1985, 57: 2344–2346？？
[5]
5 Doran J L, Leskiw B K, Aippersbach S, et al. Isolation and characterization of a beta-lactamase-inhibitory protein from Streptomyces clavuligerus and cloning and analysis of the corresponding gene. J Bacteriol, 1990, 172: 4909–4918
[6]
6 Legg B, Clarke J G, Davies B E, et al. Automated enzyme-inhibition assay for clavulanic acid in biological samples. J Pharm Biomed Anal,1985, 3: 381–384？？
[7]
7 Mendiratta D K, Kaur H, Deotale V, et al. Status of high level aminoglycoside resistant Enterococcus faecium and Enterococcus faecalis in a rural hospital of central India. Indian J Med Microbiol, 2008, 26: 369–371？？
[8]
8 Tam V H, Schilling A N, Larocco M T, et al. Prevalence of AmpC over-expression in bloodstream isolates of Pseudomonas aeruginosa. Clin Microbiol Infect, 2007, 13: 413–418？？
[9]
9 Hedberg M, Lindqvist L, Tuner K, et al. Effect of clavulanic acid, sulbactam and tazobactam on three different β-lactamases from Bacteroides uniformis, Clostridium butyricum and Fusobacterium nucleatum. J Antimicrob Chemother, 1992, 30: 17–25？？
[10]
10 O’callaghan C H, Morris A, Kirby S M, et al. Novel method for detection of β-lactamases by using a chromogenic cephalosporin substrate. Antimicrob Agents Chemother, 1972, 1: 283–288
[11]
11 Santamarta I, Rodriguez-Garcia A, Perez-Redondo R, et al. CcaR is an autoregulatory protein that binds to the ccaR and cefD-cmcI promoters of the cephamycin C-clavulanic acid cluster in Streptomyces clavuligerus. J Bacteriol, 2002, 184: 3106–3113？？
[12]
12 Fleming I D, Noble D, Noble H M, et al. Pure potassium salt of clavulanic acid. US Patent 4367175. 1983-01-04
[13]
13 Brethauer S, Held M, Panke S. High concentrations of clavulanic acid but not of its degradation products decrease glycerol consumption and oxygen uptake rates in cultures of Streptomyces clavuligerus. Biotechnol Bioeng, 2008, 100: 439–447？？
[14]
14 Stirling I, Elson S W. Studies on the biosynthesis of clavulanic acid. II. Chemical degradations of 14C-labelled clavulanic acid. J Antibiot (Tokyo), 1979, 32: 1125–1129
