19 Ho T, Wang H, Pallett D, et al. Evidence for targeting common siRNA hotspots and GC preference by plant Dicer-like proteins. FEBS Lett, 2007, 581: 3267-3272
[2]
20 Ho T, Rusholme Pilcher R L, Edwards M L, et al. Evidence for GC preference by monocot Dicer-like proteins. Biochem Biophys Res Commun, 2008, 368: 433-437
[3]
56 Cosson P, Schurdi-Levraud V, Le Q H, et al. The RTM resistance to potyviruses in Arabidopsis thaliana: natural variation of the RTM genes and evidence for the implication of additional genes. PLoS One, 2012, 7: e39169
[4]
57 Gururani M A, Venkatesh J, Upadhyaya C P, et al. Plant disease resistance genes: Current status and future directions. Physiol Mol Plant Pathog, 2012, 78: 51-65
[5]
58 Abbink T E, Tjernberg P A, Bol J F, et al. Tobacco mosaic virus helicase domain induces necrosis in N gene-carrying tobacco in the absence of virus replication. Mol Plant Microbe Interact, 1998, 11: 1242-1246
[6]
59 Burch-Smith T M, Schiff M, Caplan J L, et al. A novel role for the TIR domain in association with pathogen-derived elicitors. PLoS Biol, 2007, 5: e68
[7]
60 Dinesh-Kumar S, Baker B J. Alternatively spliced N resistance gene transcripts: their possible role in Tobacco mosaic virus resistance. Proc Natl Acad Sci USA, 2000, 97: 1908-1913
[8]
61 Liu Y, Schiff M, Dinesh-Kumar S. Involvement of MEK1 MAPKK, NTF6 MAPK, WRKY/MYB transcription factors, COI1 and CTR1 in N-mediated resistance to Tobacco mosaic virus. Plant J, 2004, 38: 800-809
[9]
62 Yamakawa H, Kamada H, Satoh M, et al. Spermine is a salicylate-independent endogenous inducer for both tobacco acidic pathogenesis-related proteins and resistance against Tobacco mosaic virus infection. Plant Physiol, 1998, 118: 1213-1222
[10]
63 Liu Y, Schiff M, Dinesh-Kumar S. Virus-induced gene silencing in tomato. Plant J, 2002, 31: 777-786
[11]
64 Liu Y, Schiff M, Serino G, et al. Role of SCF ubiquitin-ligase and the COP9 signalosome in the N gene-mediated resistance response to Tobacco mosaic virus. Plant Cell, 2002, 14: 1483-1496
[12]
65 Liu Y, Burch-Smith T, Schiff M, et al. Molecular chaperone Hsp90 associates with resistance protein N and its signaling proteins SGT1 and Rar1 to modulate an innate immune response in plants. J Biol Chem, 2004, 279: 2101-2108
[13]
66 Jin H, Axtell M J, Dahlbeck D, et al. NPK1, an MEKK1-like mitogen-activated protein kinase kinase kinase, regulates innate immunity and development in plants. Dev Cell, 2002, 3: 291-297
[14]
67 Jin H, Liu Y, Yang K Y, et al. Function of a mitogen-activated protein kinase pathway in N gene-mediated resistance in tobacco. Plant J, 2003, 33: 719-731
[15]
68 Peart J R, Mestre P, Lu R, et al. NRG1, a CC-NB-LRR protein, together with N, a TIR-NB-LRR protein, mediates resistance against Tobacco mosaic virus. Curr Biol, 2005, 15: 968-973
[16]
69 Pumplin N, Voinnet O. RNA silencing suppression by plant pathogens: defence, counter-defence and counter-counter-defence. Nat Rev Microbiol, 2013, 11: 745-760
[17]
70 Caplan J L, Mamillapalli P, Burch-Smith T M, et al. Chloroplastic protein NRIP1 mediates innate immune receptor recognition of a viral effector. Cell, 2008, 132: 449-462
[18]
71 Padmanabhan M S, Ma S, Burch-Smith T M, et al. Novel positive regulatory role for the SPL6 transcription factor in the N TIR-NB-LRR receptor-mediated plant innate immunity. PLoS Pathog, 2013, 9: e1003235
[19]
72 Li F, Pignatta D, Bendix C, et al. MicroRNA regulation of plant innate immune receptors. Proc Natl Acad Sci USA, 2012, 109: 1790-1795
[20]
73 Du Y, Zhao J, Chen T, et al. Type I J-domain NbMIP1 proteins are required for both Tobacco mosaic virus infection and plant innate immunity. PLoS Pathog, 2013, 9: e1003659
[21]
74 Hatsugai N, Kuroyanagi M, Yamada K, et al. A plant vacuolar protease, VPE, mediates virus-induced hypersensitive cell death. Science, 2004, 305: 855-858
[22]
75 Liu Y, Schiff M, Czymmek K, et al. Autophagy regulates programmed cell death during the plant innate immune response. Cell, 2005, 121: 567-577
[23]
76 Chandra-Shekara A, Navarre D, Kachroo A, et al. Signaling requirements and role of salicylic acid in HRT- and rrt- mediated resistance to Turnip crinkle virus in Arabidopsis. Plant J, 2004, 40: 647-659
[24]
77 Chandra-Shekara A, Venugopal S C, Barman S R, et al. Plastidial fatty acid levels regulate resistance gene-dependent defense signaling in Arabidopsis. Proc Natl Acad Sci USA, 2007, 104: 7277-7282
[25]
78 Chandra-Shekara A, Gupte M, Navarre D, et al. Light-dependent hypersensitive response and resistance signaling against Turnip crinkle virus in Arabidopsis. Plant J, 2006, 45: 320-334
[26]
79 Kang H G, Kuhl J C, Kachroo P, et al. CRT1, an Arabidopsis ATPase that interacts with diverse resistance proteins and modulates disease resistance to Turnip crinkle virus. Cell Host Microbe, 2008, 3: 48-57
[27]
80 Kang H G, Choi H W, von Einem S, et al. CRT1 is a nuclear-translocated MORC endonuclease that participates in multiple levels of plant immunity. Nature Commun, 2012, 3: 1297
[28]
81 Zhu S, Jeong R D, Lim G H, et al. Double-stranded RNA-binding protein 4 is required for resistance signaling against viral and bacterial pathogens. Cell Rep, 2013, 4: 1168-1184
[29]
82 Kachroo P, Yoshioka K, Shah J, et al. Resistance to Turnip crinkle virus in Arabidopsis is regulated by two host genes and is salicylic acid dependent but NPR1, ethylene, and jasmonate independent. Plant Cell, 2000, 12: 677-690
[30]
83 Takahashi H, Miller J, Nozaki Y, et al. RCY1, an Arabidopsis thaliana RPP8/HRT family resistance gene, conferring resistance to Cucumber mosaic virus requires salicylic acid, ethylene and a novel signal transduction mechanism. Plant J, 2002, 32: 655-667
[31]
84 Takahashi H, Shoji H, Ando S, et al. RCY1-mediated resistance to Cucumber mosaic virus is regulated by LRR domain-mediated interaction with CMV(Y) following degradation of RCY1. Mol Plant Microbe Interact, 2012, 25: 1171-1185
[32]
87 Komatsu K, Hashimoto M, Ozeki J, et al. Viral-induced systemic necrosis in plants involves both programmed cell death and the inhibition of viral multiplication, which are regulated by independent pathways. Mol Plant Microbe Interact, 2010, 23: 283-293
[33]
88 Rairdan G J, Collier S M, Sacco M A, et al. The coiled-coil and nucleotide binding domains of the potato Rx disease resistance protein function in pathogen recognition and signaling. Plant Cell, 2008, 20: 739-751
[34]
89 Tameling W I, Baulcombe D C. Physical association of the NB-LRR resistance protein Rx with a Ran GTPase-activating protein is required for extreme resistance to Potato virus X. Plant Cell, 2007, 19: 1682-1694
[35]
90 Tameling W I, Nooijen C, Ludwig N, et al. RanGAP2 mediates nucleocytoplasmic partitioning of the NB-LRR immune receptor Rx in the Solanaceae, thereby dictating Rx function. Plant Cell, 2010, 22: 4176-4194
[36]
91 Harris C J, Slootweg E J, Goverse A, et al. Stepwise artificial evolution of a plant disease resistance gene. Proc Natl Acad Sci USA, 2013, 110: 21189-21194
[37]
92 Weber H, Pfitzner A J. Tm-22 resistance in tomato requires recognition of the carboxy terminus of the movement protein of Tomato mosaic virus. Mol Plant Microbe Interact, 1998, 11: 498-503
[38]
93 Lanfermeijer F C, Dijkhuis J, Sturre M J, et al. Cloning and characterization of the durable tomato mosaic virus resistance gene Tm-22 from Lycopersicon esculentum. Plant Mol Biol, 2003, 52: 1039-1051
[39]
94 Lanfermeijer F C, Warmink J, Hille J. The products of the broken Tm-2 and the durable Tm-22 resistance genes from tomato differ in four amino acids. J Exp Bot, 2005, 56: 2925-2933
[40]
95 Kobayashi M, Yamamoto-Katou A, Katou S, et al. Identification of an amino acid residue required for differential recognition of a viral movement protein by the Tomato mosaic virus resistance gene Tm-22. J Plant Physiol, 2011, 168: 1142-1145
[41]
96 Brading P A, Hammond-Kosack K E, Parr A, et al. Salicylic acid is not required for Cf-2-and Cf-9-dependent resistance of tomato to Cladosporium fulvum. Plant J, 2000, 23: 305-318
[42]
97 Zhang H, Zhao J, Liu S, et al. Tm-22 confers different resistance responses against Tobacco mosaic virus dependent on its expression level. Mol Plant, 2013, 6: 971-974
[43]
98 Zhao J, Liu Q, Zhang H, et al. RuBisCO small subunit is involved in Tobamovirus movement and Tm-22-mediated extreme resistance. Plant Physiol, 2012: 374-383
[44]
99 Yamaji Y, Maejima K, Komatsu K, et al. Lectin-mediated resistance impairs plant virus infection at the cellular level. Plant Cell, 2012, 24: 778-793
[45]
100 Bilgin D D, Liu Y, Schiff M, et al. P58IPK, a plant ortholog of double-stranded RNA-dependent protein kinase PKR inhibitor, functions in viral pathogenesis. Dev Cell, 2003, 4: 651-661
[46]
101 Verlaan M G, Hutton S F, Ibrahem RM, et al. The Tomato yellow leaf curl virus resistance genes Ty-1 and Ty-3 are allelic and code for DFDGD-class RNA-dependent RNA polymerases. PLoS Genet, 2013, 9: e1003399
[47]
102 Li F, Huang C, Li Z, Zhou X. Suppression of RNA silencing by a plant DNA virus satellite requires a host calmodulin-like protein to repress RDR6 expression. PLoS Pathog, 2014, 10: e1003921Ruffel S, Dussault M H, Palloix A, et al. A natural recessive resistance gene against Potato virus Y in pepper corresponds to the eukaryotic initiation factor 4E (eIF4E). Plant J, 2002, 32: 1067-1075
[48]
85 Lu R, Malcuit I, Moffett P, et al. High throughput virus-induced gene silencing implicates heat shock protein 90 in plant disease resistance. EMBO J, 2003, 22: 5690-5699
[49]
86 Bot？r M, Amigues B, Peart J, et al. Structural and functional analysis of SGT1 reveals that its interaction with HSP90 is required for the accumulation of Rx, an R protein involved in plant immunity. Plant Cell, 2007, 19: 3791-3804
[50]
1 Herman M, Williams M E. Fighting for their lives: plants and pathogens. Plant Cell, 2012, 24: 1-15
[51]
2 Jones J D, Dangl J L. The plant immune system. Nature, 2006, 444: 323-329
[52]
3 Schwessinger B, Ronald P C. Plant innate immunity: perception of conserved microbial signatures. Annu Rev Plant Biol, 2012, 63: 451-482
[53]
4 Napoli C, Lemieux C, Jorgensen R. Introduction of a chimeric chalcone synthase gene into petunia results in reversible co-suppression of homologous genes in trans. Plant Cell, 1990, 2: 279-289
[54]
5 Van der Krol A R, Mur L A, Beld M, et al. Flavonoid genes in petunia: addition of a limited number of gene copies may lead to a suppression of gene expression. Plant Cell, 1990, 2: 291-299
[55]
6 Eamens A, Wang M B, Smith N A, et al. RNA silencing in plants: yesterday, today, and tomorrow. Plant Physiol, 2008, 147: 456-468
[56]
7 Wingard S A. Hosts and symptoms of ring spot, a virus disease of plants. J Agric Res, 1928, 37: 127-153
[57]
8 Baulcombe D. RNA silencing in plants. Nature, 2004, 431: 356-363
[58]
9 Rochow W, Ross AF. Virus multiplication in plants doubly infected by Potato viruses X and Y. Virology, 1955, 1: 10-27
[59]
10 Mlotshwa S, Pruss G J, Vance V. Small RNAs in viral infection and host defense. Trends Plant Sci, 2008, 13: 375-382
[60]
11 Ratcliff F, Harrison B D, Baulcombe D C. A similarity between viral defense and gene silencing in plants. Science, 1997, 276: 1558-1560
[61]
12 Voinnet O, Baulcombe D C. Systemic signalling in gene silencing. Nature, 1997, 389: 553
[62]
13 Voinnet O, Vain P, Angell S, et al. Systemic spread of sequence-specific transgene RNA degradation in plants is initiated by localized introduction of ectopic promoterless DNA. Cell, 1998, 95: 177-187
[63]
14 Anandalakshmi R, Pruss G J, Ge X, et al. A viral suppressor of gene silencing in plants. Proc Natl Acad Sci USA, 1998, 95: 13079-13084
[64]
15 Voinnet O. Origin, biogenesis, and activity of plant microRNAs. Cell, 2009, 136: 669-687
[65]
16 Carthew R W, Sontheimer E J. Origins and mechanisms of miRNAs and siRNAs. Cell, 2009, 136: 642-655
[66]
17 Ding S W. RNA-based antiviral immunity. Nat Rev Immunol, 2010, 10: 632-644
[67]
18 Hamilton A J, Baulcombe D C. A species of small antisense RNA in posttranscriptional gene silencing in plants. Science, 1999, 286: 950-952
[68]
21 Romaine C, Zaitlin M. RNA-dependent RNA polymerases in uninfected and Tobacco mosaic virus-infected tobacco leaves: viral-induced stimulation of a host polymerase activity. Virology, 1978, 86: 241-253
[69]
22 Dorssers L, Zabel P, van Der Meer J, et al. Purification of a host-encoded RNA-dependent RNA polymerase from Cowpea mosaic virus-infected cowpea leaves. Virology, 1982, 116: 236-249
[70]
23 Dalmay T, Hamilton A, Rudd S, et al. An RNA-dependent RNA polymerase gene in Arabidopsis is required for posttranscriptional gene silencing mediated by a transgene but not by a virus. Cell, 2000, 101: 543-553
[71]
24 Mourrain P, Béclin C, Elmayan T, et al. Arabidopsis SGS2 and SGS3 genes are required for posttranscriptional gene silencing and natural virus resistance. Cell, 2000, 101: 533-542
[72]
25 Yang S J, Carter S A, Cole A B, et al. A natural variant of a host RNA-dependent RNA polymerase is associated with increased susceptibility to viruses by Nicotiana benthamiana. Proc Natl Acad Sci USA, 2004, 101: 6297-6302
[73]
26 Qu F, Ye X, Hou G, et al. RDR6 has a broad-spectrum but temperature-dependent antiviral defense role in Nicotiana benthamiana. J Virol, 2005, 79: 15209-15217
[74]
27 Schwach F, Vaistij F E, Jones L, et al. An RNA-dependent RNA polymerase prevents meristem invasion by Potato virus X and is required for the activity but not the production of a systemic silencing signal. Plant Physiol, 2005, 138: 1842-1852
[75]
28 Qi X, Bao F S, Xie Z. Small RNA deep sequencing reveals role for Arabidopsis thaliana RNA-dependent RNA polymerases in viral siRNA biogenesis. PLoS One, 2009, 4: e4971
[76]
29 Ying X B, Dong L, Zhu H, et al. RNA-dependent RNA polymerase 1 from Nicotiana tabacum suppresses RNA silencing and enhances viral infection in Nicotiana benthamiana. Plant Cell, 2010, 22: 1358-1372
[77]
30 Mlotshwa S, Voinnet O, Mette M F, et al. RNA silencing and the mobile silencing signal. Plant Cell, 2002, 14: S289-S301
[78]
31 Kalantidis K, Schumacher H T, Alexiadis T, et al. RNA silencing movement in plants. Biol Cell, 2008, 100: 13-26
[79]
32 Ding S W, Voinnet O. Antiviral immunity directed by small RNAs. Cell, 2007, 130: 413-426
[80]
33 Cui X, Li G, Wang D, et al. A begomovirus DNA β-encoded protein binds DNA, functions as a suppressor of RNA silencing, and targets the cell nucleus. J Virol, 2005, 79: 10764-10775
[81]
34 Vance V, Vaucheret H. RNA silencing in plants-defense and counterdefense. Science, 2001, 292: 2277-2280
[82]
35 Kasschau K D, Carrington J C. Long-distance movement and replication maintenance functions correlate with silencing suppression activity of potyviral HC/Pro. Virology, 2001, 285: 71-81
[83]
36 Kasschau K D, Xie Z, Allen E, et al. P1/HC-Pro, a viral suppressor of RNA silencing, interferes with Arabidopsis development and miRNA function. Dev Cell, 2003, 4: 205-217
[84]
37 Garcia-Ruiz H, Takeda A, Chapman E J, et al. Arabidopsis RNA-dependent RNA polymerases and dicer-like proteins in antiviral defense and small interfering RNA biogenesis during Turnip mosaic virus infection. Plant Cell, 2010, 22: 481-496
[85]
38 Silhavy D, Burgyán J. Effects and side-effects of viral RNA silencing suppressors on short RNAs. Trends Plant Sci, 2004, 9: 76-83
[86]
39 Mérai Z, Kerényi Z, Kertész S, et al. Double-stranded RNA binding may be a general plant RNA viral strategy to suppress RNA silencing. J Virol, 2006, 80: 5747-5756
[87]
40 Hemmes H, Lakatos L, Goldbach R, et al. The NS3 protein of Rice hoja blanca tenuivirus suppresses RNA silencing in plant and insect hosts by efficiently binding both siRNAs and miRNAs. RNA, 2007, 13: 1079-1089
[88]
41 Kurihara Y, Inaba N, Kutsuna N, et al. Binding of tobamovirus replication protein with small RNA duplexes. J Gen Virol, 2007, 88: 2347-2352
[89]
42 Li J, Yang Z, Yu B, et al. Methylation protects miRNAs and siRNAs from a 3'' -end uridylation activity in Arabidopsis. Curr Biol, 2005, 15: 1501-1507
[90]
43 Yu B, Yang Z, Li J, et al. Methylation as a crucial step in plant microRNA biogenesis. Science, 2005, 307: 932-935
[91]
44 Csorba T, Bovi A, Dalmay T, et al. The p122 subunit of Tobacco mosaic virus replicase is a potent silencing suppressor and compromises both small interfering RNA-and microRNA-mediated pathways. J Virol, 2007, 81: 11768-11780
[92]
45 Akbergenov R, Si-Ammour A, Blevins T, et al. Molecular characterization of geminivirus-derived small RNAs in different plant species. Nucleic Acids Res, 2006, 34: 462-471
[93]
46 Kachroo A, Kachroo P. Salicylic acid-, jasmonic acid-and ethylenemediated regulation of plant defense signaling, Genet Eng(NY), 2007, 28: 55-83
[94]
47 Martin G B, Bogdanove A J, Sessa G. Understanding the functions of plant disease resistance proteins. Annu Rev Plant Biol, 2003, 54: 23-61
[95]
48 Venugopal S C, Jeong R D, Mandal M K, et al. Enhanced disease susceptibility 1 and salicylic acid act redundantly to regulate resistance gene-mediated signaling. PLoS Genet, 2009, 5: e1000545
[96]
49 Elmore J M, Lin Z J, Coaker G. Plant NB-LRR signaling: upstreams and downstreams. Curr Opin Plant Biol, 2011, 14: 365-371
[97]
50 Truniger V, Aranda M. Recessive resistance to plant viruses. Adv Virus Res, 2009, 75: 119-231
[98]
51 Mandadi K K, Scholthof K B. Plant immune responses against viruses: how does a virus cause disease? Plant Cell, 2013, 25: 1489-1505
[99]
52 Zvereva A S, Pooggin M M. Silencing and innate immunity in plant defense against viral and non-viral pathogens. Viruses, 2012, 4: 2578-2597
[100]
53 K？rner C J, Klauser D, Niehl A, et al. The immunity regulator BAK1 contributes to resistance against diverse RNA viruses. Mol Plant Microbe Interact, 2013, 26: 1271-1280
[101]
54 Bendahmane A, Kanyuka K, Baulcombe D C. The Rx gene from potato controls separate virus resistance and cell death responses. Plant Cell, 1999, 11: 781-791
[102]
55 Li B, Hu F, Zhang Q, et al. A cellular gene as a double surveillance agent for plant to combat pathogen. Plant Signal Behav, 2013, 8: e26817
