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主动脉弓各压力感受器分工编码不同范围的血压变化

, PP. 694-701

Keywords: 血压压力感受器,去极化阻滞,感受域,家兔减压神经,单纤维记录

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Abstract:

包括温度感受器、机械感受器在内的许多感受器中,各单个感受器的感受域显著不同,分工编码刺激的不同强度范围,因而保证感觉中枢明确区分刺激的水平和感知刺激的变化.主动脉弓压力感受器是血压变化的感受装置.以往研究认为,血压升高募集更多的压力感受器产生传入放电,表明各个压力感受器启始传入放电时对应的血压水平不同.然而,压力感受器是否随血压升高终止放电,各个感受器终止放电的血压水平是否不同,尚未见报道.本研究系统观察了家兔主动脉弓压力感受器随血压升高启始和终止放电的血压水平,发现不同的压力感受器产生传入放电的血压范围具有显著差异.压力感受器可能通过去极化阻滞的机制随血压升而高终止放电.研究确认,主动脉弓压力感受器具有明确有限的感受域,不同感受器分工感受不同范围的血压变化.观察的85个感受器中,近1/2的感受域的上限压力阈值存在于动脉血压的生理范围内,在血压的生理范围,募集的压力感受器数目已经达到最大,编码血压进一步升高需要通过放电频率增加或者其他途径实现.本文以新颖结果确认主动脉弓压力感受器群体,利用各个感受器不同的感受域进行群体分工编码,更新了关于动脉血压压力感受器的经典观点,提示动脉血压的神经调节可能具有更为细致的新机制,因而具有基础性的科学意义.

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