4 Discher D E, Mooney D J, Zandstra P W. Growth factors, matrices, and forces combine and control stem cells. Science, 2009, 324: 1673-1677
[2]
5 Chowdhury F, Li Y, Poh Y C, et al. Soft substrates promote homogeneous self-renewal of embryonic stem cells via downregulating cell-matrix tractions. PLoS One, 2010, 5: e15655
[3]
6 Estes B T, Gimble J M, Guilak F. Mechanical signals as regulators of stem cell fate. Curr Top Dev Biol, 2004, 60: 91-126
[4]
7 Levenstein M E, Ludwig T E, Xu R H, et al. Basic fibroblast growth factor support of human embryonic stem cell self-renewal. Stem Cells, 2006, 24: 568-574
[5]
46 Lü D Y, Liu X F, Gao Y X, et al. Asymmetric migration of human keratinocytes under mechanical stretch and cocultured fibroblasts in a wound repair model. PLoS One, 2013, 8: e74563
48 Yuge L, Kajiume T, Tahara H, et al. Microgravity potentiates stem cell proliferation while sustaining the capability of differentiation. Stem Cells Dev, 2006, 15: 921-929
[8]
49 Kawahara Y, Manabe T, Matsumoto M, et al. LIF-free embryonic stem cell culture in simulated microgravity. PLoS One, 2009, 4: e6343
[9]
50 Lei X H, Ning L N, Cao Y J, et al. NASA-approved rotary bioreactor enhances proliferation of human epidermal stem cells and supports formation of 3D epidermis-like structure. PLoS One, 2011, 6: e26603
[10]
51 Lei X H, Deng Z L, Zhang H S, et al. Rotary suspension culture enhances mesendoderm differentiation of embryonic stem cells through modulation of Wnt/b-catenin pathway. Stem Cell Rev Rep, 2014, doi: 10.1007/s12015-014-9511-6
[11]
52 Friedland J C, Lee M H, Boettiger D. Mechanically activated integrin switch controls a5b1 function. Science, 2009, 323: 642-644
[12]
53 Somlyo A P, Somlyo A V. Signal transduction by G-proteins, rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II. J Physiol, 2000, 522: 177-185
[13]
54 Grashoff C, Hoffman B D, Brenner M D, et al. Measuring mechanical tension across vinculin reveals regulation of focal adhesion dynamics. Nature, 2010, 466: 263-266
[14]
55 Guilluy C, Swaminathan V, Garcia-Mata R, et al. The Rho GEFs LARG and GEF-H1 regulate the mechanical response to force on integrins. Nat Cell Biol, 2011, 13: 722-727
[15]
56 Dupont S, Morsut L, Aragona M, et al. Role of YAP/TAZ in mechanotransduction. Nature, 2011, 474: 179-183
[16]
57 Hahn C, Schwartz M A. Mechanotransduction in vascular physiology and atherogenesis. Nat Rev Mol Cell Biol, 2009, 10: 53-62
[17]
58 Wang N, Tytell J D, Ingber D E. Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus. Nat Rev Mol Cell Biol, 2009, 10: 75-82
[18]
59 Tullio A N, Accili D, Ferrans V J, et al. Nonmuscle myosin II-B is required for normal development of the mouse heart. Proc Natl Acad Sci USA, 1997, 94: 12407-12412
[19]
60 Conti M A, Even-Ram S, Liu C, et al. Defects in cell adhesion and the visceral endoderm following ablation of nonmuscle myosin heavy chain II-A in mice. J Biol Chem, 2004, 279: 41263-41266
[20]
61 Watanabe K, Ueno M, Kamiya D, et al. A ROCK inhibitor permits survival of dissociated human embryonic stem cells. Nat Biotechnol, 2007, 25: 681-686
[21]
62 Li D, Zhou J, Wang L, et al. Integrated biochemical and mechanical signals regulate multifaceted human embryonic stem cell functions. J Cell Biol, 2010, 191: 631-644
[22]
19 Paszek M J, Zahir N, Johnson K R, et al. Tensional homeostasis and the malignant phenotype. Cancer Cell, 2005, 8: 241-254
[23]
20 Connelly J T, Gautrot J E, Trappmann B, et al. Actin and serum response factor transduce physical cues from the microenvironment to regulate epidermal stem cell fate decisions. Nat Cell Biol, 2010, 12: 711-718
[24]
21 Engler A J, Sen S, Sweeney H L, et al. Matrix elasticity directs stem cell lineage specification. Cell, 2006, 126: 677-689
[25]
22 Fu J, Wang Y K, Yang M T, et al. Mechanical regulation of cell function with geometrically modulated elastomeric substrates. Nat Methods, 2010, 7: 733-736
[26]
23 Chowdhury F, Na S, Li D, et al. Material properties of the cell dictate stress-induced spreading and differentiation in embryonic stem cells. Nat Mater, 2010, 9: 82-88
[27]
24 Liu J, Tan Y, Zhang H, et al. Soft fibrin gels promote selection and growth of tumorigenic cells. Nat Mater, 2012, 11: 734-741
[28]
25 Du J, Chen X, Liang X, et al. Integrin activation and internalization on soft ECM as a mechanism of induction of stem cell differentiation by ECM elasticity. Proc Natl Acad Sci USA, 2011, 108: 9466-9471
[29]
26 Nelson C M, Bissell M J. Modeling dynamic reciprocity: engineering three-dimensional culture models of breast architecture, function, and neoplastic transformation. Semin Cancer Biol, 2005, 15: 342-352
[30]
27 McBeath R, Pirone D M, Nelson C M, et al. Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitment. Dev Cell, 2004, 6: 483-495
29 Li Z, Gong Y, Sun S, et al. Differential regulation of stiffness, topography, and dimension of substrates in rat mesenchymal stem cells. Biomaterials, 2013, 34: 7616-7625
[33]
30 Lü D Y, Luo C H, Zhang C, et al. Differential regulation of morphology and stemness of mouse embryonic stem cells by substrate stiffness and topography. Biomaterials, 2014, 35: 3945-3955
[34]
31 Watt F M, Jordan P W, O''Neill C H. Cell shape controls terminal differentiation of human epidermal keratinocytes. Proc Natl Acad Sci USA, 1988, 85: 5576-5580
[35]
32 Ben-Ze''ev A. The role of changes in cell shape and contacts in the regulation of cytoskeleton expression during differentiation. J Cell Sci Suppl, 1987, 8: 293-312
[36]
33 Ren X D, Kiosses W B, Schwartz M A. Regulation of the small GTP-binding protein Rho by cell adhesion and the cytoskeleton. EMBO J, 1999, 18: 578-585
[37]
34 Hancock J F. Ras proteins: different signals from different locations. Nat Rev Mol Cell Biol, 2003, 4: 373-384
[38]
35 Riveline J P, Capeau J, Robert J J, et al. Extreme subcutaneous insulin resistance successfully treated by an implantable pump. Diabetes Care, 2001, 24: 2155-2156
[39]
36 Chen C S, Alonso J L, Ostuni E, et al. Cell shape provides global control of focal adhesion assembly. Biochem Biophys Res Commun, 2003, 307: 355-361
[40]
37 Adamo L, Garcia-Cardena G. Directed stem cell differentiation by fluid mechanical forces. Antioxid Redox Signal, 2011, 15: 1463-1473
[41]
38 Yamamoto K, Sokabe T, Watabe T, et al. Fluid shear stress induces differentiation of Flk-1-positive embryonic stem cells into vascular endothelial cells in vitro. Am J Physiol Heart Circ Physiol, 2005, 288: H1915-H1924
[42]
39 Adamo L, Naveiras O, Wenzel P L, et al. Biomechanical forces promote embryonic haematopoiesis. Nature, 2009, 459: 1131-1135
[43]
40 Toh Y C, Voldman J. Fluid shear stress primes mouse embryonic stem cells for differentiation in a self-renewing environment via heparan sulfate proteoglycans transduction. FASEB J, 2011, 25: 1208-1217
[44]
41 Glossop J R, Cartmell S H. Effect of fluid flow-induced shear stress on human mesenchymal stem cells: differential gene expression of IL1B and MAP3K8 in MAPK signaling. Gene Expr Patterns, 2009, 9: 381-388
[45]
42 Yourek G, Mccormick S M, Mao J J, et al. Shear stress induces osteogenic differentiation of human mesenchymal stem cells. Regen Med, 2010, 5: 713-724
[46]
43 Kurpinski K, Chu J, Hashi C, et al. Anisotropic mechanosensing by mesenchymal stem cells. Proc Natl Acad Sci USA, 2006, 103: 16095-16100
[47]
44 Kurpinski K, Chu J, Wang D, et al. Proteomic profiling of mesenchymal stem cell responses to mechanical strain and TGF-beta1. Cell Mol Bioeng, 2009, 2: 606-614
17 Long M, Sato M, Lim C T, et al. Advances in experiments and modeling in micro- and nano-biomechanics: a mini review. Cell Mole Bioeng, 2011, 4: 327-339
[50]
18 Discher D E, Janmey P, Wang Y L. Tissue cells feel and respond to the stiffness of their substrate. Science, 2005, 310: 1139-1143
[51]
1 Griffith L G, Naughton G. Tissue engineering-current challenges and expanding opportunities. Science, 2002, 295: 1009-1014
[52]
2 Demehri S, Kopan R. Notch signaling in bulge stem cells is not required for selection of hair follicle fate. Development, 2009, 136: 891-896
[53]
3 Janmey P A, Mcculloch C A. Cell mechanics: integrating cell responses to mechanical stimuli. Annu Rev Biomed Eng, 2007, 9: 1-34
[54]
8 Woll P S, Morris J K, Painschab M S, et al. Wnt signaling promotes hematoendothelial cell development from human embryonic stem cells. Blood, 2008, 111: 122-131
[55]
9 Xu R H, Sampsell-Barron T L, Gu F, et al. NANOG is a direct target of TGFbeta/activin-mediated SMAD signaling in human ESCs. Cell Stem Cell, 2008, 3: 196-206
[56]
10 Smith J R, Vallier L, Lupo G, et al. Inhibition of Activin/Nodal signaling promotes specification of human embryonic stem cells into neuroectoderm. Dev Biol, 2008, 313: 107-117
[57]
11 Ying Q L, Nichols J, Chambers I, et al. BMP induction of Id proteins suppresses differentiation and sustains embryonic stem cell self-renewal in collaboration with STAT3. Cell, 2003, 115: 281-292
[58]
12 Ingber D E, Tensegrity I. Cell structure and hierarchical systems biology. J Cell Sci, 2003, 116: 1157-1173
[59]
13 Parker K K, Brock A L, Brangwynne C, et al. Directional control of lamellipodia extension by constraining cell shape and orienting cell tractional forces. FASEB J, 2002, 16: 1195-1204
[60]
14 Carter D R, Wong M. Modelling cartilage mechanobiology. Philos Trans R Soc B-Biol Sci, 2003, 358: 1461-1471
[61]
15 Holmvall K, Camper L, Johansson S, et al. Chondrocyte and chondrosarcoma cell integrins with affinity for collagen type II and their response to mechanical stress. Exp Cell Res, 1995, 221: 496-503
[62]
16 Stewart M P, Helenius J, Toyoda Y, et al. Hydrostatic pressure and the actomyosin cortex drive mitotic cell rounding. Nature, 2011, 469: 226-230
