35 Lim S, Yoon J W, Kang S M, et al. EGb761, a Ginkgo biloba extract, is effective against atherosclerosis in vitro, and in a rat model of type 2 diabetes. PLoS One, 2011, 6: e20301
[2]
36 Jiao Y B, Rui Y C, Li T J, et al. Expression of pro-inflammatory and anti-inflammatory cytokines in brain of atherosclerotic rats and effects of Ginkgo biloba extract. Acta Pharmacol Sin, 2005, 26: 835-839
[3]
37 Rodriguez M, Ringstad L, Schafer P, et al. Reduction of atherosclerotic nanoplaque formation and size by Ginkgo biloba (EGb 761) in cardiovascular high-risk patients. Atherosclerosis, 2007, 192: 438-444
[4]
38 Wei J M, Wang X, Gong H, et al. Ginkgo suppresses atherosclerosis through downregulating the expression of connexin 43 in rabbits. Arch Med Sci, 2013, 9: 340-346
[5]
39 Mansour S M, Bahgat A K, El-Khatib A S, et al. Ginkgo biloba extract (EGb 761) normalizes hypertension in 2K, 1C hypertensive rats: role of antioxidant mechanisms, ACE inhibiting activity and improvement of endothelial dysfunction. Phytomedicine, 2011, 18: 641-647
[6]
40 Kubota Y, Tanaka N, Kagota S, et al. Effects of Ginkgo biloba extract feeding on salt-induced hypertensive Dahl rats. Biol Pharm Bull, 2006, 29: 266-269
42 El-Boghdady N A. Increased cardiac endothelin-1 and nitric oxide in adriamycin-induced acute cardiotoxicity: protective effect of Ginkgo biloba extract. Indian J Biochem Biophys, 2013, 50: 202-209
5 van Beek T A, Montoro P. Chemical analysis and quality control of Ginkgo biloba leaves, extracts, and phytopharmaceuticals. J Chromatogr A, 2009, 1216: 2002-2032
[21]
6 Corey E J, Kang M C, Desai M, et al. Total synthesis of (±)-ginkgolides B. J Am Chem, 1988, 110: 649-651
[22]
7 Nakanishi K. Terpene trilactones from Gingko biloba: from ancient times to the 21st century. Bioorgan Med Chem, 2005, 13: 4987-5000
[23]
8 Cho H J, Nam K S. Inhibitory effect of ginkgolide B on platelet aggregation in a cAMP- and cGMP- dependent manner by activated MMP-9. J Biochem Mol Biol, 2007, 40: 678-683
17 Lu S, Guo X, Zhao P. Effect of Ginkgo biloba extract 50 on immunity and antioxidant enzyme activities in ischemia reperfusion rats. Molecules, 2011, 16: 9194-9206
20 Schneider R, Welt K, Aust W, et al. Cardiac ischemia and reperfusion in spontaneously diabetic rats with and without application of EGb 761: I. Cardiomyocytes. Histol Histopathol, 2008, 23: 807-817
23 Qiao Z Y, Huang J H, Ma J W, et al. Ginkgo biloba extract reducing myocardium cells apoptosis by regulating apoptotic related proteins expression in myocardium tissues. Mol Biol Rep. 2014, 41: 347-353
27 Zhao X, Yao H, Yin H L, et al. Ginkgo biloba extract and ginkgolide antiarrhythmic potential by targeting hERG and ICa-L channel. J Pharmacol Sci, 2013, 123: 318-327
31 Tsai J Y, Su K H, Shyue S K, et al. EGb761 ameliorates the formation of foam cells by regulating the expression of SR-A and ABCA1: role of haem oxygenase-1. Cardiovasc Res, 2010, 88: 415-423
[47]
32 Chen J S, Huang P H, Wang C H, et al. Nrf-2 mediated heme oxygenase-1 expression, an antioxidant-independent mechanism, contributes to anti-atherogenesis and vascular protective effects of Ginkgo biloba extract. Atherosclerosis, 2011, 214: 301-309
[48]
33 Bicknell K A, Surry E L, Brooks G. Targeting the cell cycle machinery for the treatment of cardiovascular disease. J Pharm Pharmacol, 2003, 55: 571-591
