1 Rodrigo R, Cauli O, Gomez-Pinedo U, et al. Hyperammonemia induces neuroinflammation that contributes to cognitive impairment in rats with hepatic encephalopathy. Gastroenterology, 2010, 139: 675-684
[2]
2 Brusilow S W. Hyperammonemic encephalopathy. Medicine, 2002, 81: 240-249
[3]
3 Felipo V, Butterworth R F. Neurobiology of ammonia. Prog Neurobiol, 2002, 67: 259-279
[4]
4 Lajtha A, Reith M E A. Handbook of Neurochemistry and Molecular Neurobiology. 3rd ed. New York: Kluwer Academic/Plenum Publishers Press, 2008
[5]
5 Basile A S, Jones E A. Ammonia and GABA-ergic neurotransmission: interrelated factors in the pathogenesis of hepatic encephalopathy. Hepatology, 1997, 25: 1303-1305
[6]
6 Montoliu C, Piedrafita B, Serra M A, et al. IL-6 and IL-18 in blood may discriminate cirrhotic patients with and without minimal hepatic encephalopathy. J Clin Gastroenterol, 2009, 43: 272-279
[7]
7 Gibertini M, Newton C, Friedman H, et al. Spatial learning impairment in mice infected with legionella pneumophila or administered exogenous interleukin-1-β. Brain Behav Immun, 1995, 9: 113-128
[8]
10 Murphy D L, Moya P R, Fox M A, et al. Anxiety and affective disorder comorbidity related to serotonin and other neurotransmitter systems: obsessive-compulsive disorder as an example of overlapping clinical and genetic heterogeneity. Philos Trans R Soc B-Biol Sci, 2013, 368: 20120435
[9]
11 Bergqvist P B F, Hjorth S, Audet R M, et al. Ammonium acetate challenge in experimental chronic hepatic encephalopathy induces a transient increase of brain 5-HT release in vivo. Eur Neuropsychopharm, 1996, 6: 317-322
[10]
12 R?ssle M, Luft M, Herz R, et al. Amino acid, ammonia and neurotransmitter concentrations in hepatic encephalopathy: serial analysis in plasma and cerebrospinal fluid during treatment with an adapted amino acid solution. Klin Wochenschr, 1984, 62: 867-875
[11]
13 Miura H, Ozaki N, Sawada M. A link between stress and depression: shifts in the balance between the kynurenine and serotonin pathways of tryptophan metabolism and the etiology and pathophysiology of depression. Stress, 2008, 11: 198-209
[12]
14 Vignau J, Costisella O, Canva V, et al. Impact of interferon alpha immunotherapy on tryptophan metabolism in patients with chronic hepatitis C. Results of a pilot studies on ten patients (in French). Encephale, 2009, 35: 477-483
[13]
15 Laugeray A, Launay J M, Callebert J. Peripheral and cerebral metabolic abnormalities of the tryptophan-kynurenine pathway in a murine model of major depression. Behav Brain Res, 2010, 210: 84-91
[14]
16 Butterworth R F, Norenberg M D, Felipo V, et al. Experimental models of hepatic encephalopathy: ISHEN guidelines. Liver Int, 2009, 29: 783-788
[15]
17 Lena P J, Subramanian P. Effects of melatonin on the levels of antioxidants and lipid peroxidation products in rats treated with ammonium acetate. Pharmazie, 2004, 59: 636-639
[16]
18 Moroni F, Lombardi G, Moneti G, et al. The release and neosynthesis of glutamic acid are increased in experimental models of hepatic encephalopathy. J Neurochem, 1983, 40: 850-854
[17]
19 Subash S, Subramanian P. Morin a flavonoid exerts antioxidant potential in chronic hyperammonemic rats: a biochemical and histopathological study. Mol Cell Biochem, 2009, 327: 153-161
[18]
20 Bajaj J S, Sanyal A J, Bell D, et al. Predictors of the recurrence of hepatic encephalopathy in lactulose-treated patients. Aliment Pharmacol Ther, 2010, 31: 1012-1017
[19]
21 Flamm S L. Rifaximin treatment for reduction of risk of overt hepatic encephalopathy recurrence. Therap Adv Gastroenterol, 2011, 4: 199-206
[20]
22 Nicaise C, Prozzi D, Viaene E, et al. Control of acute, chronic, and constitutive hyperammonemia by wild-type and genetically engineered Lactobacillus plantarum in rodents. Hepatology, 2008, 48: 1184-1192
[21]
23 Isolauri E, Sütas Y, Kankaanp?? P, et al. Probiotics: effects on immunity. Am J Clin Nutr, 2001, 73: 444S-450S
[22]
24 Steidler L, Hans W, Schotte L, et al. Treatment of murine colitis by Lactococcus lactis secreting interleukin-10. Science, 2000, 289: 1352-1355
[23]
25 Desbonnet L, Garrett L, Clarke G, et al. The probiotic Bifidobacteria infantis: an assessment of potential antidepressant properties in the rat. J Psychiatr Res, 2008, 43: 164-174
[24]
26 Gareau M G, Wine E, Rodrigues D M, et al. Bacterial infection causes stress-induced memory dysfunction in mice. Gut, 2011, 60: 307-317
[25]
27 Benton D, Williams C, Brown A. Impact of consuming a milk drink containing a probiotic on mood and cognition. Eur J Clin Nutr, 2007, 61: 355-361
[26]
28 Rao A V, Bested A C, Beaulne T M, et al. A randomized, double-blind, placebo-controlled pilot study of a probiotic in emotional symptoms of chronic fatigue syndrome. Gut Pathog, 2009, 1: 6
[27]
29 Bravo J A, Forsythe P, Chew M V, et al. Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Proc Natl Acad Sci USA, 2011, 108: 16050-16055
[28]
30 Joo H M, Kim K A, Myoung K S, et al. Lactobacillus helveticus HY7801 ameliorates vulvovaginal candidiasis in mice by inhibiting fungal growth and NF-κB activation. Int Immunopharmacol, 2012, 14: 39-46
[29]
8 Wiltfang J, Nolte W, Wei?enborn K, et al. Psychiatric aspects of portal-systemic encephalopathy. Metab Brain Dis, 1998, 13: 379-389
[30]
9 Erecinska M, Pastuszko A, Wilson D F, et al. Ammonia-induced release of neurotransmitters from rat brain synaptosomes: differences between the effects on amines and amino acids. J Neurochem, 1987, 49: 1258-1265
[31]
31 Ohland C L, Kish L, Bell H, et al. Effects of Lactobacillus helveticus on murine behavior are dependent on diet and genotype and correlate with alterations in the gut microbiome. Psychoneuroendocrinology, 2013, 38: 1738-1747
[32]
32 Gokcimen A, Kocak A, Gulle K, et al. The effects of allopurinol on rat liver and spleen tissues in a chronic hyperammonemia animal model. Saudi Med J, 2007, 28: 1648-1653
[33]
33 Sgouras D, Maragkoudakis P, Petraki K, et al. In vitro and in vivo inhibition of Helicobacter pylori by Lactobacillus casei strain Shirota. Appl Environ Microbiol, 2004, 70: 518-526
[34]
34 Walf A A, Frye C A. The use of the elevated plus maze as an assay of anxiety-related behavior in rodents. Nat Protoc, 2007, 2: 322-328
[35]
35 Wolfer D P, Stagljar-Bozicevic M, Errington M L, et al. Spatial memory and learning in transgenic mice: fact or artifact? Physiology, 1998, 13: 118-123
[36]
36 Monfort P, Cauli O, Montoliu C, et al. Mechanisms of cognitive alterations in hyperammonemia and hepatic encephalopathy: therapeutical implications. Neurochem Int, 2009, 55: 106-112
[37]
37 Reznikov L, Fadel J, Reagan L. Glutamate-mediated neuroplasticity deficits in mood disorders. In: Costa e Silva J A, Macher J P, Olié J P, eds. Neuroplasticity. London: Springer Healthcare, 2009. 13-26
[38]
38 Cauli O, Rodrigo R, Piedrafita B, et al. Inflammation and hepatic encephalopathy: ibuprofen restores learning ability in rats with portacaval shunts. Hepatology, 2007, 46: 514-519
[39]
40 Riedel C U, Foata F, Philippe D, et al. Anti-inflammatory effects of bifidobacteria by inhibition of LPS-induced NF-kB activation. World J Gastroenterol, 2006, 12: 3729-3735
[40]
41 Aragon G, Graham D B, Borum M, et al. Probiotic therapy for irritable bowel syndrome. Gastroenterol Hepatol, 2010, 6: 39-44
[41]
42 Laugeray A, Launay J M, Callebert J, et al. Evidence for a key role of the peripheral kynurenine pathway in the modulation of anxiety- and depression-like behaviours in mice: focus on individual differences. Pharmacol Biochem Behav, 2011, 98: 161-168
[42]
43 Iversen S D. 5-HT and anxiety. Neuropharmacology, 1984, 23: 1553-1560
[43]
44 Jennings K A, Loder M K, Sheward W J, et al. Increased expression of the 5-HT transporter confers a low-anxiety phenotype linked to decreased 5-HT transmission. J Neurosci, 2006, 26: 8955-8964
[44]
45 Dejong C H C, van de Poll M C G, Soeters P B, et al. Aromatic amino acid metabolism during liver failure. J Nutr, 2007, 137: 1579S-1585S
[45]
46 O''Connor J C, André C, Wang Y, et al. Interferon-γ and tumor necrosis factor-α mediate the upregulation of Indoleamine 2,3-dioxygenase and the induction of depressive-like behavior in mice in response to bacillus calmette-guérin. J Neurosci, 2009, 29: 4200-4209
[46]
47 D?ubener W, Schmidt S K, Heseler K, et al. Antimicrobial and immunoregulatory effector mechanisms in human endothelial cells. Indoleamine 2,3-dioxygenase versus inducible nitric oxide synthase. Thromb Haemost, 2009, 102: 1110-1116
[47]
48 Gurtner G J, Newberry R D, Schloemann S R, et al. Inhibition of indoleamine 2,3-dioxygenase augments trinitrobenzene sulfonic acid colitis in mice. Gastroenterology, 2003, 125: 1762-1773
[48]
49 Forsythe P, Inman M D, Bienenstock J. Oral treatment with live Lactobacillus reuteri inhibits the allergic airway response in mice. Am J Respir Crit Care Med, 2007, 15: 561-569
[49]
50 Valladares R, Bojilova L, Potts A H, et al. Lactobacillus johnsonii inhibits indoleamine 2,3-dioxygenase and alters tryptophan metabolite levels in BioBreeding rats. FASEB J, 2013, 27: 1711-1720
[50]
51 Wu H Q, Pereira E F, Bruno J P, et al. The astrocyte-derived α7 nicotinic receptor antagonist kynurenic acid controls extracellular glutamate levels in the prefrontal cortex. J Mol Neurosci, 2010, 40: 204-210
[51]
52 Cortese B M, Mitchell T R, Galloway M P, et al. Region-specific alteration in brain glutamate: possible relationship to risk-taking behavior. Physiol Behav, 2010, 99: 445-450
[52]
39 Khasnavis S, Jana A, Roy A, et al. Suppression of nuclear factor-κB activation and inflammation in microglia by a physically-modified saline. J Biol Chem, 2012, 287: 29529-29542