Keloid disease is a fibro proliferative skin tumor and occurs after a skin
trauma in genetically vulnerable individuals. Etiology of keloid is unclear. Causative
factors for keloid are increased familial aggregation, a higher prevalence in certain
races, parallelism in identical twins, and alteration in gene expression. It appears
that the surroundings activate the disease in genetically susceptible individuals.
Several genes are considered responsible for keloid disease, but no single gene
mutation has thus far been found to be responsible. Therefore, we should apply a
combination of methods such as association, gene-gene interaction, epigenetics,
linkage, gene expression, and protein analysis to find out the keloid etiology.
Incidence of familial keloid is common in Africans but is uncommon in Indian population.
It may be due to autosomal dominant or autosomal recessive inheritance.
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