We present the case of a 24-year-old man, who was a keen runner, developing chronic bilateral lower leg compartment syndrome following co-administration of Risperidone and Sodium Valproate. Having had failed medical and physical therapies, he underwent surgical decompression of his more problematic left lower leg compartments. In the interval between sequential fasciotomies, control of his psychiatric symptoms allowed the dose of his Risperidone to be reduced, resulting in a greater exercise tolerance. Ultimately he no longer required the contra-lateral lower leg compartments to be decompressed surgically. He had returned to his original level of activity with no further psychotic episodes.
References
[1]
Could Risperidone Cause Compartment Syndrome. eHealthMe.com [Internet]. Cited 13 February 2014. http://www.ehealthme.com/ds/risperidone/compartment+syndrome
[2]
Webber, M.A., Mahmud, W., Lightfoot, J.D. and Shekhar, A. (2004) Rhabdomyolysis and Compartment Syndrome with Coadministration of Risperidone and Simvastatin. Journal of Psychopharmacology, 18, 432-434.
[3]
Ramdass, M.J., Singh, G. and Andrews, B. (2007) Simvastatin-Induced Bilateral Leg Compartment Syndrome and Myonecrosis Associated with Hypothyroidism. Post-graduate Medicine Journal, 83, 152-153.
[4]
Walker, J.L., Smith, G.H., Gaston, M.S. and Robinson, C.M. (2008) Spontaneous Compartment Syndrome in Association with Simvastatin-Induced Myositis. Emergency Medicine Journal, 25, 305-306.
[5]
Committee, J.F. (2013) British National Formulary (BNF) 66. Pharmaceutical Press, London, 1128.
