Silica aerogel (SA) was loaded with
domperidone to demonstrate the potentiality of adsorption processes based on
the usage of supercritical carbon dioxide to treat poorly water-soluble drugs,
forming new kinds of drug delivery systems. The effects of pressure,
temperature and solution concentration on loaded SA were studied. Adsorption
isotherms were measured at 35℃ and 45℃ and fitted with Langmuir model.
Release kinetics of the adsorbed drug were also evaluated
by in vitro dissolution tests.
Results showed that domperidone can be uniformly dispersed into the aerogel and
that the release rate of domperidone from the composite, constituted by drug
and silica aerogel, is much faster than that of the crystalline drug. The
proposed adsorption method is suitable for the production of domperidone fast
release tablets.
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