TECHNIQUES TO ENHANCE SOLUBILITY OF POORLY SOLUBLE DRUGS: A REVIEW

Solubility is essential for the therapeutic effectiveness of the drug, independent of the route of administration. Poorly soluble drugs are often a challenging task for formulators in the industry. Conventional approaches for enhancement of solubility have limited applicability, especially when the drugs are poorly soluble simultaneously in aqueous and in non-aqueous media. Solubilization may be affected by cosolvent water interaction, micellar solubilization, reduction in particle size, inclusion complexes, solid dispersion, and change in polymorph. Some new technologies are also available to increase the solubility like microemulsion, self emulsifying drug delivery system and supercritical fluid technology. This review focuses on the recent techniques of solubilization for the attainment of effective absorption and improved bioavailability