Solubility Estimation of Structurally Related Drugs in Binary Solvent Mixtures

Two empirical models for predicting solubility of structurally related drugs in binary solvent mixtures have been given. The accuracy and prediction capability of models were compared with those of a previously published model. Results indicated that the new models were superior to the previous model. Key words: Structurally related drugs, Solubility, Binary solvent mixtures