CMP Promoters Database: A systematic study on site-specific transcription factors in CMP genes

CMPP Database (Central Metabolic Pathway Promoter Database)consists of manually annotated regulatory sequences/motif of genescontrolling Metabolic Pathways (http://cmpp.biodbs.info) such asGlycolysis’ and Krebs’ cycle. The CMPP software package writtenin Microsoft Visual Basics & MS Access was also developed forsearching & updating the CMPP database. This database wasfurther used to study the relationship between 10 transcriptionfactors involved in the non-coding upstream region of CMP genes.There is an existence of common motifs between the genesencoding enzymes involved in glycolysis and Krebs cycle revealingan evolutionary relation between the genes of the two pathways.However, some of the common motif such as TATA uncommonmotifs as NKX and AP2 making up the structural feature of the noncoding genes are absent from few genes.