COMPARATIVE EVALUATION OF EXTRACTS OF C. IGNEUS (OR C. PICTUS) FOR HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITY IN ALLOXAN DIABETIC RATS.

Aims: To compare the possible therapeutic effects of C. igneus methanolic and aqueous extractsagainst hyperglycemic and hyperlipidemic activity in alloxan induced diabetic rats.Materials and Methods: Blood glucose level, serum lipid profile and pancreas histology as well as phytochemical investigations were estimated after administration of the both extracts at dose level of50, 100 and 200 mg/kg were comparable to that of glibenclamide (0.5mg/kg).Result: All studies in aqueous and methanolic extracts of Costus igneus have shown better effect on end of 30th day. The significantly reduce type 2 diabetes in rats and regulation of insulin secretion,islet protection as well as produce higher antidiabetic compounds by methanolic extract at dose level of 200 mg/kg.Conclusion: Our results suggest that the Costus igneus methanolic extract anti-diabetic activity is slightly higher to the aqueous extract and good agreement with the folk medicinal use of this plant.