Hypoglycemic Activity of Ethanolic Extract of Solanum nigrum Linn. Leaves on Alloxan Induced Diabetes Mellitus in Rats

Diabetes is a metabolic disorder associated with hyperglycemia and caused by defect in insulin secrtion. Past few year some of the new bioactive drug isolated from plants showed anti- diabetic activity in clinical therapy . Hypoglycemic effect of these plant is due to their ability to restore the function of pancreatic β cells by causing an increase in insulin output or inhibit the intestinal absorption of glucose. Hence treatment with herbal drugs has an effect on protecting β cells and smoothing out fluctuation inglucose level. In present study we have screened alcoholic extracts of Solanum nigrum leaves for hypoglycemic effect in Albino rats. Different doses of alcoholic extract 50, 100, 200, 400 mg/kg of body weight were employed to evaluate alloxan induced diabetes with reference to standared Glibenclamide. Results indicated the alcoholic extract of leaves possesses significant hypoglycemic effect in dose dependent manner.