Attenuation of Fructose Induced Hyperlipidemia of Enicostemma axillare

Hypercholesterolemia has become the leading cause for the development of various diseases. It has drawn the attention of pharmaceutical companies to turn towards the herbal products, having fewer side effects. Preliminary phytochemical analyses were carried out in different extracts of Enicostemma axillare (EA) like hexane, chloroform, ethyl acetate and 85 % methanol. The hypocholesterolaemic effect of 85 % methanolic extract of EA were evaluated in fructose induced hyperlipidemic animals. Antioxidant enzymes such as catalase, TBARS, GSH, GST and lipid profile such as cholesterol, LDL, VLDL, HDL and triglycerides were analysed inheart and plasma samples. Administration of EA decreases the lipid profile and TBARS significantly (p<0.05). Likewise, EA administration increases the antioxidant activity and HDL significantly (p<0.05).The results reveal that EA is a rich source for phytoconstituents like tannin, Vitamin C and Vitamin E and can be used as a potent hypocholesterolemic and antioxidant agent in pharmaceutical industry. In the present research, the hypocholesterolaemic activity of EA along with their phytochemical evaluation has been done.