Direct Passerini Reaction of Aldehydes, Isocyanides, and Aliphatic Alcohols Catalyzed by Bismuth (III) Triflate

Bismuth (III) triflate was found to be effective Lewis acid catalyst for direct alkylative Passerini reaction of aldehydes, isocyanides, and aliphatic alcohols. In the present reaction, α-unsaturated and aromatic aldehydes used as substrates produced the corresponding α-alkoxy amide products in good yield.