Synthesis of 3-substitutedmethylene-2H-thiopyrano[2,3-b] Pyridine-4(3H)-ones and Their Antifungal Activity In Vitro

Six (Z)-3-substitutedmethylene-2H-thiopyrano[2,3-b]pyridin-4(3H)-ones were designed and synthesized. Their structures were confirmed by MS and 1H-NMR and element analysis. Their antifungal activity was tested by micro dilution broth susceptibility for eight kinds of fungi, and the results showed that the target compounds exhibited activity against fungi tested to some extent. The compound 5a had the best antifungal effect among of the target compounds.