Microwave Assisted Synthesis of Cobalt Phosphate Nanoparticles and Their Antiproliferation against Human Lung Cancer Cells and Primary Osteoblasts in Vitro

In this research, different nanostructures of cobalt phosphate nanoparticles were successfully prepared. Platelike and spherical cobalt phosphate were made by microwave synthesis method without any use of capping agent as structure directors. The reaction was completed under two different microwave irradiation power (500 W and 800 W) and times (5 min and 10 min) for the production of two types of cobalt phosphate nanoparticles. The synthesized nanoparticles were characterized by field emission scanning electron microscopy (FE-SEM), powder x-ray diffraction (XRD), BET, fourier transform infrared spectroscopy (FTIR) and dynamic light scattering (DLS). The SEM images showed that the flowerlike nanostructure was an arrangement of cobalt phosphate plates with thickness of 80 nm and the average size of spherical cobalt phosphate nanoparticles was about 40 nm. Antiproliferation activity of cobalt phosphate nanoparticles as a function of particle concentration against human lung cancer cells and primary osteoblasts were carried out in vitro. The spherical nanoparticles showed better antiproliferation activity than the platelike nanoparticles and primary osteoblasts were more sensitive than human lung cancer cells to cobalt phosphate nanoparticles.