EVALUATION OF BIOCHEMICAL PARAMETERS IN PATIENTS OF MYOCARDIAL INFARCTION

Objective: To estimate routine biochemical parameters Liver Function Tests, Kidney Function Tests, Serum Electrolytes, Calcium, phosphorus, total protein, albumin and Fasting Plasma Glucose in patients of Myocardial Infarction and compare with controls to evaluate if any of them can be used as a supportive marker of CAD risk assessment. Material Methods: Study group had 50 patients of documented Myocardial Infarction and 50 age and sex matched controls. Investigations were carried out on venous blood samples collected from subjects after overnight fasting which included LFT (S. Bilirubin, ALT ,AST,ALP), KFT (B.Urea, S.Creatinine, S.Uric acid) , S .Electrolytes (S. Sodium, S.Potassium) S.Calcium and S. Phosphate and Fasting Plasma Glucose .These chemistries were carried out in fully automated clinical chemistry analyzer, Beckman (SYNCHRON CX9) using standard reagents/kits. Results: Fasting plasma glucose (p<0.01) , Uric Acid(p<0.01) and Calcium (p<0.05)was found to be significantly higher in study group compared to control group Conclusion: In the rural areas with dearth of good laboratory and healthcare services, these can be evaluated to be used as simple and cost effective biochemical markers of CAD risk although they are to be used in conjunction with other markers. However, more longitudinal and prospective studies are required to find a causal relationship between these routine biochemical markers (uric acid, Fasting plasma glucose, calcium) and myocardial infarction in Indian Population