PHARMACOKINETICS FOR DOSE PROPORTION; OF 250 MG CEFACLOR TABLET IN MALE VOLUNTEERS ESTIMATIO

To estimate dose proportion for male volunteers by calculating pharmacokinetics following oral administration ofCefaclor (CCL) 250mg Tablet and to check the relative susceptibility of four bacterial strains Design: Randomized Clinical Trial, case series.Setting: Department of Chemistry and Biochemistry, University of Agriculture, Faisalabad. Period: From Mar 2006 to Feb 2007. Materials andmethods: Blood samples were collected for the period of 12 hours in heparinized tubes. Collected samples were centrifuged at 3000xg andplasma thus separated was stored at -10 C until further analysis. The CCL plasma concentration was determined via bioassay using discdiffusion method. Pharmacokinetics parameters were calculated using American Pharmacology Organization (APO) computer software.Results and conclusion: Renal Clearance (CL), Volume of distribution (VD), Time of Peak (T ), Maximum plasma concentration (C ), max maxMean Residence Time (MRT), Absorption half life, Elimination half life & the Area Under plasma Concentration (AUC ) showed that the four t0 to t12hbacterial strains have different susceptibility against cefaclor and administration of cefaclor at rate of 250 mg as tablet orally thrice dailymaintained considerable concentration (>MIC) that prove it to be very effective for the treatment of specific infections in male volunteers.