In-Vivo Animal Models For Evaluation Of Anti-Inflammatory Activity

Inflammation is protective and defense mechanism of the body. During inflammatory conditions various pathological changes are take place. The production of active inflammatory mediators is triggered by microbial products or by host proteins, such as proteins of the complement, kinins and coagulation systems that are themselves are activated by microbes and damaged tissues. In preclinical studies, these changes can be induced by administration of the agents causing inflammation. For purpose of evaluation of anti-inflammatory activity we have focused on some in vivo animal models which are commonly used in laboratory practice. Numerous reports have been demonstrated in increase incidence of inflammatory condition. It is one of the most important natural defence mechanisms. Its main purpose is to destroy the injurious agent and/or to minimize its ill effects by limiting its spread. Though inflammation is protective in some situations if untreated can lead to serious complications. Inflammation is the dynamic pathological process consisting of a series of interdependent changes.