Recent trends - Fast dissolving tablets

Two widely faced challenges in oral drug delivery are pill-swallowing difficulty and delivery of unpalatable drugs.Pill-swallowing difficulty primarily affects the geriatric and pediatric populations whereas unpalatable taste of drugs leads to patient non-compliance. To eliminate these problems, a new dosage form known as fast-dissolving tablet (FDT), has been developed like fast-melt or fast disintegrating or orally disintegrating tablets (ODTs). In April 2007, the FDA issued a draft guidance, Guidance for Industry: Orally Disintegrating Tablets. Fast dissolving tablets can be prepared by various conventional methods like direct compression, wet granulation, moulding, spray drying, freeze drying, and sublimation. In 1986, the first lyophilized fast-dissolving technology Zydis was introduced (By Cardinal formerly R. P. Scherer) after that there was a continuous growth in names by different companies, now a number of fast-dissolving formulations are in market and the technology is still improving. Present review focuses on the need of FDTs, their advantages and comparative evaluation of latest technologies. Keywords: fast dissolving tablet, orasolv, durasolv, patents