A Review : Supercritical Fluid Extraction Technology

This study includes information concerning supercritical fluid. The technology of supercritical fluid (SCF) and supercritical fluid extraction offers an opportunity to efficient and economically improve recovery, increase reproducibility, decrease use of halogenated solvents and provide cleaner extract to the measurement instrument.Previously to bring about the easier dissolution of relatively insoluble material some physical action to the solvent like application of pressure or change in the temperature were found to be effective but to a certain extent. Apart from the key of using supercritical fluid as an efficient solvent at its critical point has been shown its applicability in various types processing such solvent for some specialized chemical reaction1. SCF technology is making in-roads in several pharmaceutical industrial operations including crystallization, medium for particle design and engineering, particle size reduction, preparation of drug delivery systems, coating, and product sterilization. It has also been shown to be a viable option in the formulation of particulate drug delivery systems, such as micro particles and nanoparticles, liposomes, and inclusion complexes, which control drug delivery and/or enhance the drug stability2.