The Effects of a Classic Spartathlon Race on Lipids and Prostanoids in Endurance Male Athletes

The aim of this study was to examine the effect of a classic Spartathlon race, which means continuous running for 246 km, on the concentration of 2,3 dinor 6-keto-prostaglandin (2, 3 dinor 6-keto PGF1a), the urinary metabolite of the prostacyclin (PGI2), 2, 3-dinor-thromboxane B2 (2, 3 dinor TXB2), the urinary metabolite of thromboxane A2 (TXB2), the 2, 3 dinor 6-keto-PGF1a:2, 3 dinor-TXB2 ratio, Total Cholesterol (TC), Triglycerides (TG), High-Density Lipoprotein Cholesterol (HDL-C), Low-Density Lipoprotein-L (LDL-L) and the TC: HDL-C ratio. It was hypothesized that these parameters would be changed after the completion of the Sparthathlon. For this study proposes blood and urine samples were obtained from19 male athletes, all of which finished the Spartathlon race in <35 h, before, at the end of and 24 h after the race. After result analysis, the levels of all the substances measured were different at the end of the race compared with before the race and these altered levels remained 24 h after the race. Importantly, it was observed that metabolism of 2, 3 dinor-6 keto-PGF1a at the end of the race was fourfold than before the race (p<0.001) and the concentration of 2, 3 dinor TXB2 after the race was tenfold than before the race (p<0.001).