The comparison of insulin resistance frequency in patients with recurrent early pregnancy loss to normal individuals

Present case- control prospective study was performed on 100 women in control group (with a history of at a live birth and no history of one more abortion) and study group (with a history of ≥ 3 RMS) who were not diabetes and PCOS. Two groups matched in base of age and body mass index. Blood was withdrawn from the case and control patients for the determination of the fasting blood glucose (FG), fasting insulin (FI) levels and ultrasonography was performed on all the patients.The observed differences between age, FG and FG to FI ratio levels in case and control groups were not significant (p > 0.05) but it was significant about fasting insulin (p = 0.0119). FI of < 20 μu/ml or ≥ 20 μu/ml in case and control group was significant (Chi-square: 4.083, p: 0.0433, odds ratio: 4.4386, CI95% = 1.1541 to 17.0701), whereas the difference between absolute and proportional frequency of patients with FG to FI ratio of < 4.5 and ≥ 4.5 in case and control groups was not significant (Chi-square: 2.374, p = 0.123).Current study showed that in women with RPL, in Iranian race like Americans, frequency of insulin resistance in high, therefore there is a probability of the degree of insulin resistance in women with RPL.Recurrent pregnancy loss (RPL) is estimated to occur in 2%-4% of reproductive -age couples [1]. Patients with ≥ 3 recurrent spontaneous miscarriages are classified as having RSM. An RSM remains is a very disturbing event to the affected patients by this health problem; they are always anxious to find the underlying reasons for their miscarriages. This is also a major challenge to the treating physicians [2]. It is a major hazard in pregnancy, both for naturally conceived and those after assisted reproductive technology (ART) treatment [3].Intensive researches including immunological and genetic studies are still in progress to illustrate the cause of RSM [2]. Chromosome anomaly, uterine malformations or anomalies, hypothyroidism, cervical in competence, anti phospholipid