The gastric protective effects of Morchella conica on the ethanol- induced gastric mucosal lesion in rats
尖顶羊肚菌对急性酒精性胃黏膜损伤保护作用研究

The effects of Morchella conica mycelial extract on the ethanol-induced gastric mucosal lesion of rats in vivo were investigated. The gastric mucosal lesion was induced by 95% ethanol, the lesion index was measured and the superoxide dismutase (SOD), malonaldehyde (MDA), glutathione (GSH) content in the gastric issues were tested. The gastric acid, pepsin and gastric mucus were detected in ligated pyloru rats. The result showed that the middle dose and high dose of M. conica mycelial extract could reduce the lesion index of gastric mucosal (p<0.05); M. conica did not inhibit the gastric secretion (p>0.05) but promoted the pepsin and gastric mucus secretion (p<0.05); The SOD activity and the GSH content were reduced, and the MDA content was increased after the rats were gavages by 95% ethanol, but these situations were reversed in M. conica treated groups. These results indicated that protective effects of M. conica against the ethanol induced gastric lesions were related to its effects of promoting gastric mucus and improving the antioxidant activity.