Effects of quinolones on activity of hepatic drug-metabolizing enzymes in Paralichthys olivaceus
喹诺酮类药物对牙鲆肝药物代谢酶活性的影响

In order to observe the difference of effects of quinolones on the activity of drug-metabolism(cytochrome P-450),we studied the effects of quinolones(FQ)on the activities of APND,ERND and EROD in the liver of flounders(Paralichthys olivaceus).The results showed that the activities of APND,ERND and EROD in the S_9 mix were inhibited by the three kinds of quinolones on the different degrees,where enrofloxacin and norfloxacin treated groups had a very significant decrease on the activities of APND,ERND and EROD compared to the control group(P＜0.01),while flumequine treated group only decreased the activity of EROD very significantly(P＜0.01),and had a significant decrease on the activities of APND and ERND.