RETENTION OF FISSION PRODUCT 170Tm AND ITS MUTAGENIC EFFECT ON BONE MARROW CELLS
裂变产物170Tm的体内蓄积特性诱发骨髓细胞突变效应研究

After injection of 170Tm with a dose of 1.85×104kBq/kg to male Wistar rats, the radioactivities of tissue samples were determined at different intervals by homogeneous scintillation counting. The retention data were well described by a three exponential expressions. Retentive t1/2, in the rats ranged from 1.25 d for the fast component to 257 d for the slow one. Retention dynamics of 170Tm in the body showed that from very early stage its accumulation in the skeleton began to increase steadily and its radioactivity ranked first in all tissues until the day 91. The study on the chromosome aberration of bone marrow cells indicated that chromosome aberration was of the chromatid type and its rate increased with elevation of absorption dose of 170Tm in the bone.