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Marine Drugs  2012 

Lochmolins A–G, New Sesquiterpenoids from the Soft Coral Sinularia lochmodes

DOI: 10.3390/md10071572

Keywords: soft coral, Sinularia lochmodes, sesquiterpenes, aromadendrane, germacrane

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Abstract:

Seven new sesquiterpenoids, lochmolins A–G ( 1– 7), were isolated from a Taiwanese soft coral Sinularia lochmodes. The structures of these metabolites were elucidated by extensive spectroscopic study. Compounds 1– 4 were found to inhibit the accumulation of the LPS-induced pro-inflammatory COX-2 protein in RAW264.7 macrophage cells.

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