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Marine Drugs  2006 

The Chemistry and Pharmacology of Anatoxin-a and Related Homotropanes with respect to Nicotinic Acetylcholine Receptors

DOI: 10.3390/md403228

Keywords: anatoxin-a, homoanatoxin, UB165, pinnamine, homotropane, nicotinic acetylcholine receptor, pharmacophore

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Abstract:

This chapter covers the chemistry and nicotinic pharmacology of naturally occurring homotropane alkaloids, with an emphasis of anatoxin-a. In addition to anatoxin-a, homoanatoxin and pinnamine, as well as the major classes of synthetic derivatives of anatoxin-a including UB-165, are discussed.

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