AN EVALUATION OF SECURITY FOR KINGPANAX FRESH Panax notoginseng JUICE IN MUTAGENIC AND TERATOGENIC TESTS OF MAMMAL
金不换鲜三七液对哺乳动物致突变和致畸安全性评价

This paper was to investigate the mutagenicity of KINGPANAX fresh Panax notoginseng juice.We used chromosomal aberration test of bone marrow cells in mice,chromosomal aberration test in mouse testicle meiotic cells and teratogenicity test in mice as an indicater to study the securities of KINGPANAX fresh Panax notoginseng juice.The results were as follows:(a) Chromosomal aberration of bone marrow in mice:Frequency of chromosomal aberration of bone marrow in mice in the control group was 0 8%,the frequencies of low,middle and high dose groups were 0 7%,0 2% and 0 9% respectively.In comparison with control group,there was no significant difference,More significant increase of frequency of chromosomal aberration were found in positive control group.(b) Chromosomal aberration in mouse testicle meiotic cells:Under our experimental conditions,frequency of chromosomal aberration in mouse testicle meiotic cells (including sex chromosomal univalents X-YU],autosomal univalents AU] showed no obvious difference among various experimental groups and control group.(c) Teratogenicity test in mice:The accumulative doses of KINGPANAX fresh Panax notoginseng juice in mice by gastric instillation reached 1/10,1/5 and 1/2 of 15?g/kg body weight.No statistically significant difference in the mouse teratogenicity test was observed.According to our exparimental results,KINGPANAX fresh Panax notoginseng juice is safe for drinking and has no poisonous side effect.