While there may be many reasons why very interesting science ideas never reach commercial practice, one of the more prevalent is that the reaction or process, which is scientifically possible, cannot be made efficient enough to achieve economic viability. One pathway to economic viability for many business sectors is the multi-product portfolio. Research, development, and deployment of viable biorefinery technology must meld sound science with engineering and business economics. It is virtually axiomatic that increased value can be generated by isolating relatively pure substances from heterogeneous raw materials. Woody biomass is a heterogeneous raw material consisting of the major structural components, cellulose, lignin, and hemicelluloses, as well as minor components, such as extractives and ash. Cellulose is a linear homopolymer of D-glucopyrano-units with β-D(1?4) connections and is the wood component most resistant to chemical and biological degradation. Lignin is a macromolecule of phenylpropanoid units, second to cellulose in bio-resistance, and is the key component that is sought for removal from woody biomass in chemical pulping. Hemicelluloses are a collection of heteropolysaccharides, comprised mainly of 5- and 6-carbon sugars. Extractives, some of which have high commercial value, are a collection of low molecular weight organic and inorganic woody materials that can be removed, to some extent, under mild conditions. Applied Biorefinery Sciences, LLC (a private, New York, USA based company) is commercializing a value-optimization pathway (the ABS Process?) for generating a multi-product portfolio by isolating and recovering homogeneous substances from each of the above mentioned major and minor woody biomass components. The ABS Process? incorporates the patent pending, core biorefinery technology, “hot water extraction”, as developed at the State University of New York College of Environmental Science and Forestry (SUNY-ESF). Hot water extraction in the absence of mineral acids and bases is preferred because of its ability to generate multiple high value output products without chemical input, recovery, or disposal costs. Instead of added chemicals in the cooking phase, the ABS Process? relies upon an autocatalytic reaction in which acetyl groups, bound through an ester linkage to hemicellulose chains, are hydrolyzed at high temperature in water. The resulting acidic conditions (final pH ~3.5) and temperatures of 160–170 °C permit further solubilization and diffusion of oligomeric 5- and 6-carbon sugars, acetic acid, aromatic substances,
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