Association of PON2 Gene Polymorphisms in Neonates with Preterm
新生儿PON2基因多态性与早产的关系

The objective is to investigate whether gene polymorphisms in the PON2 gene (PON2148 and PON2311) of neonates are associated with preterm. Using standard questionnaires, 194 singleton live born mother-neonate pairs (include preterm cases and term controls) were investigated by the trained field workers with cross-sectional survey at the hospitals in Anqing, Anhui Province,China. Epidemiological and clinical data and blood samples were obtained from 194 mother-neonate pairs. Among neonates,PON2 Alal48Ala homozygote is significantly associated with preterm,compared with Glyl48Gly homozygote / Alal48Gly heterozygote before and after adjustment con-founders and the same was true for PON2 SerSllSer homozygote. However, when PON2148 polymorphism and PON2311 polymorphism were considered jointly, no significant gene interaction between PON2148 polymorphism and PON2311 polymorphism in relation to preterm was observed. We draw a conclusion from this research that both PON2148 polymorphism and PON2311 polymorphism in neonates are significantly associated with preterm respectively. But the gene interactions between PON2148 polymorphism and PON2311 polymorphism in neonates are not significantly associated with preterm.