Studies of Genetic Polymorphisms of ADH2 and ALDH2 among the Han Population in Luoyang China
洛阳市汉族群体ADH2和ALDH2的基因多态性研究

In order to investigate genetic polymorphisms of ADH2 and ALDH2 among the Han population in Luoyang City, portions of exon 3 of ADH2 and exon 12 of ALDH gene were amplified by using polymerase chain reaction. The amplified products were electrophoresed on 10% undenatured vertical polyacrylamide gels and stained with argentine. Frequencies of ADH2 * 1 and ADH2 * 2 alleles are 42. 86% and 57. 14%. Frequencies of three genotypes of ADH2 are 22. 86% ,40. 00% and 37. 14% .respectively. Frequencies of ALDH2 * 1 and ALDH2 * 2 alleles are 85.24% and 14. 76%. Genotype frequencies of ALDH2 loci are 71. 43% N27. 62% and 0. 95% respectively. Genetic polymorphisms of ADH2 and ALDH2 among the Han population in Luoyang City are different from those among Taiwanese and Shanghainese. Frequency of ALDH2 * 1 / * 1 in Luoyang people is higher than those in Shanghai and Taiwan. Therefore, there is a higher resistance to alcohol drinking in the Han population in Luoyang.