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心理学报  2011 

Hippocampal NMDA Receptor is involved in Chronic Stress Induced Depressive-Like Behaviors via SP-NK1 Receptor Pathway
海马NMDA受体经SP-NK1受体通路参与慢性应激诱发的抑郁样行为

Keywords: chronic unpredictable mild stress,depression,hippocampus,N-methyl-D-aspartic acid receptor,substance P
慢性不可预见性温和应激
,抑郁症,海马,NMDA受体,P物质

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Abstract:

Stressors markedly influence central neurochemical and hormonal processes and thus play a pivotal role in the occurrence of depressive illnesses.As the center for stress response and the potential target for stressful provocation,hippocampus is becoming a focus in depression research.Although a large number of behavioral paradigms have been proposed as animal models of depression,only a few are considered as potentially useful research tools with sufficient validity.The most accepted one is chronic unpredic...

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