Study on Association Rules of Radix Aconiti Lateralis Praeparata and Rhizoma Pinelliae from 18 Forbidden Incompatible Pairs of TCM Herbs
十八反附子半夏同方配伍的关联规则研究

This study was aimed to explore the compatibility rules of Radix Aconiti Lateralis Praeparata and Rhizoma Pinelliae belonging to the 18 forbidden incompatible pairs of traditional Chinese medicine (TCM) herbs in formulas, and to analyze their compatibility characteristics. A total of 502 formulas containing both Radix Aconiti Lateralis Praeparata and Rhizoma Pinelliae in all the past dynasties were collected to be mined by using association rules. The results showed that core herbs in the formulas containing Radix Aconiti Lateralis Praeparata and Rhizoma Pinelliae are Radix et Rhizoma Ginseng, Radix et Rhizoma Glycyrrhizae, Cortex Cinnamomi, Poria, Rhizoma Atractylodis Macrocephalae; the core pairs are Radix Aconiti Lateralis Praeparata-Rhizoma Pinelliae, Rhizoma Pinelliae-Radix et Rhizoma Ginseng, Radix et Rhizoma Ginseng-Radix Aconiti Lateralis Praeparata, Rhizoma Pinelliae -Cortex Cinnamomi; and the core groups are Radix Aconiti Lateralis Praeparata-Radix et Rhizoma Ginseng-Rhizoma Pinelliae, Radix Aconiti Lateralis Praeparata-Rhizoma Pinelliae-Radix et Rhizoma Glycyrrhizae, Radix Aconiti Lateralis Praeparata-Rhizoma Pinelliae-Cortex Cinnamomi, Radix Aconiti Lateralis Praeparata-Poria-Rhizoma Pinelliae. Besides, the compatible pairs including Radix Angelicae Sinensis -Radix Rehmanniae Praeparata, Radix Angelicae Sinensi-Radix Paeoniae Alba, Radix Astragali-Radix Angelicae Sinensis are of the highest support when cooperating with Rhizoma Pinelliae and Radix Aconiti Lateralis Praeparata. It was concluded that most of the formulas containing both Radix Aconiti Lateralis Praeparata and Rhizoma Pinelliae are for warming yang to resolve phlegm, which are usually combined with Chinese herbs for tonifying qi to strengthen the body resistance, regulating the flow of qi to invigorate the spleen, and nourishing and activating blood.