Behavioral Observation and Analysis of PMS Liver-qi Depression Rat Model Established by Chronic Restraint Stress and Resident-Intruder Paradigm
慢性束缚应激及居住入侵法制备经前期综合征肝气郁证大鼠模型的行为学观测与分析

This study was aimed to investigate the feasibility of establishing premenstrual syndrome (PMS) liver-qi depression rat model with resident-intruder paradigm compared to chronic restraint stress. PMS liver-qi depression rat model was prepared with chronic restraint stress and resident-intruder paradigm, respectively. The effect was systematically evaluated through behavioral methods such as open-field test and tail suspension test. Then, results from both groups were compared. The results showed that both chronic restraint stress and resident-intruder paradigm can effectively simulate the state of premenstrual depression and postmenstrual disappearance. The results of open-field test suggested that there was no significant difference between these two methods (P > 0.05). It was concluded that as a social psychological stress method, resident-intruder paradigm can preferably simulate the process of clinical PMS liver-qi depression caused by emotion abnormality, and overcome the disadvantage of obvious body stress of chronic restraint stress method. But the success ratio was too low, and further inspection was needed to examine its stability.