Zhen-Nao-Ning Capsules Ameliorate Migraine via Regulating Monoamine Neurotransmitters
镇脑宁胶囊治疗偏头痛作用研究

This study was aimed to evaluate the effect of Zhen -Nao -Ning capsules on experimental migraine model mice. The experimental migraine model mice were induced by injecting reserpine injection and blood clots. The pain threshold was determined by hot -plate method and monoamine neurotransmitters including norepinephrine (NE), dopamine (DA), 5-hydroxytryptamine (5-HT) and 5-hydroxy indole acetic (5-HIAA) which were measured by fluorescence spectrophotometry method. The symptom of pain among animal models can be relieved in different degrees by the treatment of Zhen -Nao -Ning capsule at the dosage of 200-800 mg/kg. The pain threshold can be increased 27% after treatment of Zhen -Nao -Ning capsule at the dosage of 800 mg/kg. And contents of NE, DA, 5-HT and 5-HIAA were increased 34%, 33%, 20%, and 30%, respectively. The results indicated that Zhen-Nao-Ning capsule can ameliorate migraine via regulating monoamine neurotransmitters.