Experimental Study on Acute Toxicity and Genetic Toxicity of Diospyros Kaki Extract
柿叶提取物对小鼠急性毒性和遗传毒性研究

This study was aimed to observe the acute oral toxicity and genetic toxicity of Diospyros kaki Extract. Acute oral toxicity test was performed in mice. The genetic toxicity of Diospyros kaki Extract was evaluated by bone marrow micronucleus and sperm shape abnormality test (Diospyros kaki Extract was administered to mice at the dosage of 0.00, 0.25, 5.00, and 10.0 g/kg BW). The results showed that the acute oral maximum-tolerated dose of Diospyros kaki Extract was greater than 597.2 g/kg, which was 2150 times of the clinical dosage. There were significant statistical differences between each dosage group and positive control group (P < 0.01) in bone marrow micronucleus and sperm shape experiment. It was concluded that the Diospyros kaki Extract was classified as non-toxic substance. There was no genetic toxicity produced.