Study on Inflammatory Mechanism between Lung and Brain by the Action of Baicalin on TLRs-NOD2 Signaling
从黄芩苷对TLRs-NOD2的调控探讨肺、脑相关炎性反应的共同机制

This study was aimed to investigate the regulation effect of baicalin on TLRs-NOD2 in cerebral ischemia model and pneumonia model in order to discuss the common pathological mechanism of both models.The cerebral ischemia reperfusion mice model and acute pneumonia mice model were established.Baicalin was intraperitoneal injected into the mice.Then,protein expressions of TLR2/4,NOD2 and TNFα in the brain and lung tissues were detected.The results showed that protein expressions of TLR2/4,NOD2 and TNFα were significantly upregulated in the brain and lung tissues of brain injury model.And baicalin is able to downregulate these factors at different levels.Protein expressions of TLR2/4,NOD2 and TNFα were increased significantly at different levels in the brain and lung tissues of the pneumonia model.Baicalin is able to inhibit these factors at different levels.It is concluded that baicalin has obvious regulation effect on TLR2/4,NOD2 and downstream inflammatory factor TNFα.This regulation effect and inflammatory mechanism may be the common basis of baicalin effect in the treatment of lung and brain diseases.