Cell sheet fabrication of hepatocyte-like cells differentiated from adipose tissue mesenchymal stem cells
大鼠脂肪间充质干细胞诱导为类肝细胞及其细胞片的制备

Adult pluripotent stem cells,such as mesenchymal stem cells derived from bone marrow and adipose tissue are capable of multilineage differentiation. Although autologous stem cell transplantation is an effective alternative to organ transplantation,the loss of cell viability and differentiation confinement of implanted cells has largely impaired the therapeutic efficacy. To produce biomaterial-free liver construct to integrate into living tissue,we isolated adipose mesenchymal stem cells and subjected them t...