METABOLISM OF PLASMA LCPOPROTEINS-CHOLESTEROL IN RABBIT IN VTVO: COMPARTMENTAL ANALYSIS
兔血浆脂蛋白-胆固醇代谢的房室模型研究

As we know, high levels of plasma LDL-Ch and low levels of HDL -Ch are strongly associated with the development of AS; but it is very important to pay more attention to the ability of plasma lipoproteins - cholesterol metabolism. Diabetes is a risk factor of AS. To compare the diabetes group of rabbits with the control, we have discussed the difference in the ability of plasma lipoproteins to transfer cholesterol.Based on the physiological and biochemical knowledge which have been understood, we established two three-compartment models so as to describe plasma cholesterol metabolism among lipoproteins, liver, and extrahapetic tissues. According to the experimental data measured, the rate constants from one compartment to another and the dynamic curves in each compartment have been estimated by means of the theory of system identificatioa These model parametres can be used to assess the ability of plasma lipoproteins in trans-fering cholesterol. From the results, we found that the ability of reverse cholesterol transport in the diabetes group was defective compared with the control. We also noted that the rate of cholesterol transport by plasma LDL from liver to extrahapetic tissues increased in the diabetes group. It is indicated that diabetes would accelerate the development of AS. We expect that this research will provide a new method and enlightenment on clinical prediction, diagnosis and treatment of AS.