NETWORK THERMODYNAMICS MODEL OF PATHWAY CONDUCTANCE FOR DRUG TRANSPORT THROUGH SKIN
药物经皮转运通道的网络热力学模型

The pathway conductance properties of epidermis for transdermal drug delivery is expounded. Quantitative relationship of the drug permeable flux passing skin with pathway consistency of epidermis in side-by-side permeation chamber is described by network thermodynamics model. It is con-sidered that pathway conductance for drug through skin is regulated by activation and inactivation factors. From completed passive (control) and electrical pulse (experiments) experiments with Tinidazole, the re-sults showed that theoretical curves of pathway conductance of epidermis fitted very well with the data from these experiments. So the conclusion is that initial activation factor (m0), time constant of activation tm), initial inactivation factor (h0), and time constant of inactivation (th) are believed to be very impor-tant indexes for analysis of property of pathway conductance of drug transport through skin.