Allele-Specific Regulation of Matrix Metalloproteinase-3 Gene by Transcription Factor NFκB

Matrix metalloproteinase-3 (MMP3) is implicated in the pathogenesis and progression of atherosclerotic lesions. Previous studies suggested that MMP3 expression is influenced by a polymorphism (known as the 5A/6A polymorphism) in the promoter of the MMP3 gene and that this polymorphism is located within a cis-element that interacts with the transcription factor NFκB. In the present study, we sought to investigate whether MMP3 and NFκB were co-localized in atherosclerotic lesions and whether NFκB had differential effects on the two alleles of the MMP3 5A/6A polymorphism.