Linfomas no hodgkinianos agresivos: ？Después del CHOP sólo el CHOP?

the aggressive nhls (non-hodgkin lymphomas) comprise the diffuse large b-cell nhls (including the variant of primary mediastinal b-cell lymphoma), the anaplastic and null large t-cell lymphomas and the peripheral t-cell lymphomas. an international prognostic index was created taking into account age, serum levels of ldh, performance status and extranodal affection. the chop scheme is considered as the gold standard of those non-hodgkin？s lymphoma of aggressive histology, both in limited and advanced disease. patients with disseminated disease have curability indexes under 40 %, so multiple therapeutic strategies are being tested to improve these results. it has been found that it is possible to increase the dose of the main drugs in the chop schemes up to approximately the double of the standard with an accepted toxicity and better responses.