Presenilinas, Apo E y enfermedad de Alzheimer

a review was made on the identification and isolation of the genes codyfing for presenilin 1 and 2 (chromosome 14 and 21, respectively), as well as on the detection of mutations, which is one of the achievements of the genetic strategy to study alzheimer？s disease. these investigations have contributed to explain a percentage of the cases with family history and early-onset affection. the apo e gene, mainly the presence of allele e4 located in chromosome 19, is associated with late-onset family alzheimer？s disease. some aspects showing the remarkable advance attained in the knowledge of the physiopathogenic events, which are subjacent to the most frequent cause of dementia and are not clear yet, are dealt with.