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Feb 26, 2021Open    AccessArticle

Natural Killer Cell-Based Immunotherapy against Solid Cancer

Pinlei Lv, Wenrui Li, Ruoyu Wang, Guojun Huang, Yi Zhu, Qiqiang Tao
As a kind of important innate lymphocytes in vivo, Natural killer (NK) cells have a rapid and efficient capacity to recognize and destroy tumor cells, senescent cells and virus-infected cells. In the past decades, NK cells have been widely applied in the treatment of hematological malignancies in clinic, even solid tumors. Successful results have been made against hematological malignancies (NCT00697671, NCT00990717, NCT00145626), but also a number of considerable challenges have been encountere...
Open Access Library J. Vol.8, 2021
Doi:10.4236/oalib.1107056


Jul 08, 2020Open    AccessArticle

Non-Carcinogenic Genotoxic Drugs Could Be Used to Prevent and Treat COVID-19

Gao-De Li
Three-dimensional (3D) genome structure plays an important role in the regulation of gene expression. Alteration of 3D genome structure can change cell’s gene expression pattern that causes cellular function change and thus could be used as a novel therapy for treating many diseases including COVID-19. Genotoxic drug is the only drug that could be used to alter 3D genome structure. Since at present no purpose-made non-carcinogenic genotoxic drugs for altering genome structure are available and f...
Open Access Library J. Vol.7, 2020
Doi:10.4236/oalib.1106536


May 15, 2020Open    AccessArticle

Targeting Three-Dimensional Genome Architecture Might Be One of the Mechanisms of Chloroquine’s Diverse Therapeutic Actions

Gao-De Li
Chloroquine (CQ) was initially synthesized as an antimalarial agent, but later on, it also shows immunomodulatory, anticancer, and antiviral effects in clinical practice. Although CQ has been used to treat various conditions for more than half century, the underlying mechanisms of its diverse therapeutic actions remain incomplete. In this paper, we hypothesize that targeting three-dimensional genome architecture might be one of the mechanisms of CQ’s diverse therapeutic actions. Based on this hy...
Open Access Library J. Vol.7, 2020
Doi:10.4236/oalib.1106340


Mar 11, 2020Open    AccessArticle

Neonatal Screening for Lubumbashi Drepacytosis: Feasibility and Suitable Performance

Tina Katamea, Criss Koba Mjumbe, Maguy Ngongo Omoy, Dieudonné Bafwafwa, Matthieu Ngombe, Lydie Kasongo, Gautier Mutoba, Dieudonné Ngwej Tshikwej, Amir Assumani N’Simbo, Oscar Luboya Numbi, Léon Tshilolo, Sanislas Wembonyama
Sickle cell anemia is a blood disorder linked to an abnormality in the structure of hemoglobin. The objective of this study was to determine the frequency of the sickle cell gene on the basis of early detection of hemoglobin using the isoelectric focusing technique in maternities in Lubumbashi. Our descriptive cross-sectional study consisted of newborns and infants up to 6 months of age. The capillary venous blood was collected on the finger for the rapid and direct test and on blotting paper fo...
Open Access Library J. Vol.7, 2020
Doi:10.4236/oalib.1106121


Jan 20, 2020Open    AccessArticle

Bromatological Analysis and Antioxidant Capacity of Hibiscus sabdariffa L. in Cuba

Francis Brown, José González, Enrique C. Cejas, Max Monan, Iván S. Sayago
Towards authentication and quality assurance of medicinal plants, calyces of Hibiscus sabdariffa L. recollected from the Experimental Station of Medicinal Plants “Dr Juan Tomas Roig” between January and April 2016 were analyzed to determine its bromatological properties (moisture content; dry matter; fat; protein; total ash; mineral contents) and its antioxidant
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Open Access Library J. Vol.7, 2020
Doi:10.4236/oalib.1105920


Jun 28, 2019Open    AccessArticle

Hypothesis on Remote Memory Forming from Heterosynaptic LTD-Mediated Neuronal Degeneration

Zi-Jian Cai
In this article, it is hypothesized a new mechanism for the formation of stable remote memory in brain comprising the important memory acquired during childhood and the common words in language. It has been demonstrated that the memory forms concurrently at both homosynaptic long term potentiation (LTP) and heterosynaptic long term depression (LTD). It is pointed out that the repeated LTD may result in neuronal degeneration as evi
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Open Access Library J. Vol.6, 2019
Doi:10.4236/oalib.1105442


Jun 28, 2019Open    AccessArticle

Flexible Cancer-Associated Chromatin Configuration (CACC) Might Be the Fundamental Reason Why Cancer Is So Difficult to Cure

Gao-De Li
We once proposed that cell-type-associated chromatin configurations determine cell types and that cancer cell type is determined by cancer-associated chromatin configuration (CACC). In this paper, we hypothesize that flexible cell-type-associated chromatin configuration is associated with cell potency and has an advantage over inflexible one in regulating genome related activities, such as DNA replication, DNA tra
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Open Access Library J. Vol.6, 2019
Doi:10.4236/oalib.1105531


Feb 28, 2019Open    AccessArticle

Formation of Cell-Type-Associated Chromatin Configurations: A Hypothesis

Gao-De Li
More than 30 years ago, we published a hypothesis in which the 3-dimen- sional structure of entire chromatin fibres in a eukaryotic cell is named as chromatin configuration that determines the pattern of gene expression in each type of cell. Based on this hypothesis, cell differentiation is the process in which different types of cells are endowed with different chromatin configura-tions. Therefore, this chrom
...
Open Access Library J. Vol.6, 2019
Doi:10.4236/oalib.1105246


Feb 01, 2019Open    AccessArticle

Further Thoughts on Abnormal Chromatin Configuration and Oncogenesis

Gao-De Li
More than 30 years ago, we published a paper entitled as “Abnormal Chromatin Configuration and Oncogenesis”, which proposed the first hy-pothesis that links oncogenesis to abnormal three-dimensional (3D) genome structure. Recently, many studies have demonstrated that the 3D genome structure plays a major role in oncogenesis, which strongly supports our hypothesis. In this paper, further thoughts about our hypothesis are presented.
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Open Access Library J. Vol.6, 2019
Doi:10.4236/oalib.1105185


Jun 26, 2018Open    AccessArticle

The Origin of Life Discovered: ΣRNA

Muying Zhou
Since 1992, scientific knowledge has been enough to determine the origin of life: “life originated through RNA”. The truth is that current life world on Earth is just an RNA world, since the protein is created by RNA, then DNA as life’s database is created by RNA along with reverse transcriptase (a protein of RNA making). The two life series on the planet originated through two RNA groups (named ΣRNA ): IΣRNA and IIΣRNA . IΣRNA
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Open Access Library J. Vol.5, 2018
Doi:10.4236/oalib.1104681


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